中老年人群中镁缺乏评分与外周动脉疾病之间的关联
Association Between Magnesium Depletion Score and Peripheral Artery Disease in Middle-Aged and Older Population.
作者信息
Cai Zongao, She Jiachen
机构信息
Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Department of Nursing, Peking Union Medical College Hospital, Beijing, 100730, China.
出版信息
J Cardiovasc Transl Res. 2025 Apr 7. doi: 10.1007/s12265-025-10615-0.
The magnesium depletion score (MDS) is considered a new valuable predictor of body magnesium status. This study aimed to explore the association between MDS and PAD among participants aged ≥ 40 years on the National Health and Nutrition Examination Survey in 1999-2004. Survey-weighted multivariable logistic regression and restricted cubic spline models were used to assess the association between MDS and PAD. Survey-weighted multivariable logistic regression showed a significant positive association between MDS and the prevalence of PAD. For each unit increase in MDS, the risk of PAD increased by 24%. Compared to individuals with MDS = 0, those with MDS ≥ 3 had a 95% higher risk of PAD. Restricted triple spline analysis showed a linear dose-response relationship between MDS and PAD risk. Subgroup analysis indicated that this positive association was stronger in individuals aged > 60 years. Numerous future longitudinal cohort studies are required to validate our findings.
镁缺乏评分（MDS）被认为是身体镁状态的一种新的有价值的预测指标。本研究旨在探讨1999 - 2004年美国国家健康与营养检查调查中年龄≥40岁的参与者中MDS与外周动脉疾病（PAD）之间的关联。采用调查加权多变量逻辑回归和受限立方样条模型来评估MDS与PAD之间的关联。调查加权多变量逻辑回归显示MDS与PAD患病率之间存在显著正相关。MDS每增加一个单位，PAD风险增加24%。与MDS = 0的个体相比，MDS≥3的个体患PAD的风险高95%。受限三次样条分析显示MDS与PAD风险之间存在线性剂量反应关系。亚组分析表明，这种正相关在年龄>60岁的个体中更强。需要大量未来的纵向队列研究来验证我们的发现。
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