结直肠癌中的锌指蛋白：对分子机制和治疗意义的见解

Zinc Finger Proteins in Colorectal Cancer: Insights into Molecular Mechanisms and Therapeutic Implications.

作者信息

Lan Chongyuan, Qiu Ming, Lin Minglin

机构信息

Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.

Guangxi Key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.

出版信息

Technol Cancer Res Treat. 2025 Jan-Dec;24:15330338251334447. doi: 10.1177/15330338251334447. Epub 2025 Apr 10.

DOI:10.1177/15330338251334447

PMID:40208082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12032436/

Abstract

Colorectal cancer ranks as one of the most common malignancies globally, with mortality rates second only to lung cancer. Despite improvements in diagnostic and therapeutic approaches, long-term survival rates for colorectal cancer patients remain unsatisfactory. The onset and progression of this disease involve intricate molecular mechanisms, influenced by a range of biological factors. Zinc finger proteins play a critical role in these processes, impacting tumor development and patient prognosis. This review summarizes current research on zinc finger proteins in colorectal cancer, highlighting key findings and advancements in understanding their role in tumor biology.

摘要

结直肠癌是全球最常见的恶性肿瘤之一，死亡率仅次于肺癌。尽管诊断和治疗方法有所改进，但结直肠癌患者的长期生存率仍不尽人意。这种疾病的发生和发展涉及复杂的分子机制，受到一系列生物学因素的影响。锌指蛋白在这些过程中起着关键作用，影响肿瘤的发展和患者的预后。本综述总结了目前关于结直肠癌中锌指蛋白的研究，突出了在理解其在肿瘤生物学中的作用方面的关键发现和进展。