抑制剂对大鼠单胺和二胺代谢的作用。
Action of inhibitors on monoamine and diamine metabolism in the rat.
作者信息
Sourkes T L, Missala K
出版信息
Can J Biochem. 1977 Jan;55(1):56-9. doi: 10.1139/o77-010.
The effects of a series of inhibitors of monoamine oxidase (EC 1.4.3.4) and diamine oxidase (EC 1.4.3.6) and of two chelating agents were studied in rats, with respect to the catabolism of labeled pentylamine and putrescine to radioactive carbon dioxide. D-Tranylcypromine, clorgyline, and deprenyl inhibited oxidation of the monoamine, with essentially no effect on putrescine, under our test conditions. Aminoguanidine inhibited putrescine but not pentylamine oxidation. Iproniazid, isoniazid, and Lilly 51641 affected the catabolism of both amines. Pargyline inhibited putrescine oxidation, apparently in a reversible manner.
就标记的戊胺和腐胺分解代谢为放射性二氧化碳而言，在大鼠中研究了一系列单胺氧化酶（EC 1.4.3.4）和二胺氧化酶（EC 1.4.3.6）抑制剂以及两种螯合剂的作用。在我们的测试条件下，D-反苯环丙胺、氯吉兰和司来吉兰抑制单胺的氧化，对腐胺基本无影响。氨基胍抑制腐胺氧化，但不抑制戊胺氧化。异烟肼、异烟腙和礼来51641影响两种胺的分解代谢。帕吉林抑制腐胺氧化，显然是以可逆方式。
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