双调蛋白对马子宫内膜成纤维细胞的作用：源自非纤维化和纤维化子宫内膜的成纤维细胞的体外反应

The effect of amphiregulin on equine endometrial fibroblasts: in vitro responses of fibroblast derived from non-fibrotic and fibrotic endometrium.

作者信息

Wójtowicz Anna, Sadowska Agnieszka, Piotrowska-Tomala Katarzyna, Szóstek-Mioduchowska Anna

机构信息

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, Olsztyn 10-683, Poland.

出版信息

Reprod Biol. 2025 Jun;25(2):101018. doi: 10.1016/j.repbio.2025.101018. Epub 2025 Apr 14.

DOI:10.1016/j.repbio.2025.101018

PMID:40222068

Abstract

The role of AREG in the development of fibrosis in the progression of endometrosis in mare remains unknown. We aimed to determine the effects of AREG on fibroblast functional characteristics as well as the expression of extracellular matrix (ECM)-associated genes in fibroblast derived from non-fibrotic and fibrotic equine endometria. Our findings suggest that the mechanisms associated with ECM remodeling regulated by AREG in non-fibrotic fibroblasts may be dysregulated in the progression of fibrosis in endometrosis.

摘要

AREG在母马子宫内膜异位症进展过程中纤维化发展中的作用尚不清楚。我们旨在确定AREG对成纤维细胞功能特性以及源自非纤维化和纤维化马子宫内膜的成纤维细胞中细胞外基质（ECM）相关基因表达的影响。我们的研究结果表明，在非纤维化成纤维细胞中由AREG调节的与ECM重塑相关的机制在子宫内膜异位症纤维化进展过程中可能失调。