氧化应激与硫化氢的双面性：对神经退行性疾病发病机制的见解

The Janus Face of Oxidative Stress and Hydrogen Sulfide: Insights into Neurodegenerative Disease Pathogenesis.

作者信息

Munteanu Constantin, Galaction Anca Irina, Onose Gelu, Turnea Marius, Rotariu Mariana

机构信息

Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iasi, Romania.

Neuromuscular Rehabilitation Clinic Division, Clinical Emergency Hospital "Bagdasar-Arseni", 041915 Bucharest, Romania.

出版信息

Antioxidants (Basel). 2025 Mar 19;14(3):360. doi: 10.3390/antiox14030360.

DOI:10.3390/antiox14030360

PMID:40227410

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11939184/

Abstract

Oxidative stress plays an essential role in neurodegenerative pathophysiology, acting as both a critical signaling mediator and a driver of neuronal damage. Hydrogen sulfide (HS), a versatile gasotransmitter, exhibits a similarly "Janus-faced" nature, acting as a potent antioxidant and cytoprotective molecule at physiological concentrations, but becoming detrimental when dysregulated. This review explores the dual roles of oxidative stress and HS in normal cellular physiology and pathophysiology, focusing on neurodegenerative disease progression. We highlight potential therapeutic opportunities for targeting redox and sulfur-based signaling systems in neurodegenerative diseases by elucidating the intricate balance between these opposing forces.

摘要

氧化应激在神经退行性疾病的病理生理学中起着至关重要的作用，既是关键的信号传导介质，也是神经元损伤的驱动因素。硫化氢（HS）作为一种多功能气体信号分子，也具有类似的“两面性”，在生理浓度下是一种强大的抗氧化剂和细胞保护分子，但当调节失调时则会产生有害作用。本综述探讨了氧化应激和HS在正常细胞生理和病理生理中的双重作用，重点关注神经退行性疾病的进展。我们通过阐明这些相反力量之间的复杂平衡，突出了针对神经退行性疾病中氧化还原和基于硫的信号系统的潜在治疗机会。