一项评估针对青少年和青年癌症幸存者的定制多组分康复计划的可行性和可接受性的试点研究。
A Pilot Study to Evaluate the Feasibility and Acceptability of a Tailored Multicomponent Rehabilitation Program for Adolescent and Young Adult (AYA) Cancer Survivors.
作者信息
Corke Lauren, Langelier David M, Gupta Abha A, Capozza Scott, Antonen Eric, Trepanier Gabrielle, Avery Lisa, Lopez Christian, Edwards Beth, Jones Jennifer M
机构信息
Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.
Institute of Medical Sciences, University of Toronto, Toronto, ON M5S3K3, Canada.
出版信息
Cancers (Basel). 2025 Mar 22;17(7):1066. doi: 10.3390/cancers17071066.
BACKGROUND
Adolescent and young adult (AYA) cancer survivors have unique needs, yet few tailored rehabilitation programs exist. CaRE-AYA is an 8-week multidimensional rehabilitation program for AYAs that targets impairments, activity limitations and participation restrictions and comprises an individualized exercise prescription and weekly group-based exercise and self-management education.
METHODS
We conducted a single-arm multi-method pragmatic feasibility study evaluating CaRE-AYA's feasibility, acceptability, and safety (primary outcomes) and assessed disability, physical functioning, mental health, and social functioning at baseline (T0), immediately post-intervention (T1), and 3 months post-intervention (T2).
RESULTS
Twenty-five participants (median age: 32.8, 76% female) were enrolled. Participation (60%), retention (84% at T1, 72% at T2), and program adherence (76% for education classes, 74% for exercise classes) supported feasibility. Qualitative interviews ( = 9) supported strong perceptions of feasibility and acceptability. No serious adverse events (≥grade 3) attributed to CaRE-AYA occurred.
CONCLUSIONS
The results suggest CaRE-AYA is feasible, acceptable, and safe. A randomized controlled trial is needed to determine the effectiveness.
背景
青少年和青年癌症幸存者有独特的需求，但针对性的康复项目却很少。“关爱青少年和青年癌症幸存者（CaRE-AYA）”是一项为期8周的针对青少年和青年癌症幸存者的多维度康复项目，该项目针对损伤、活动受限和参与限制，包括个性化运动处方以及每周一次的基于小组的运动和自我管理教育。
方法
我们进行了一项单臂多方法实用可行性研究，评估CaRE-AYA的可行性、可接受性和安全性（主要结局），并在基线（T0）、干预后即刻（T1）和干预后3个月（T2）评估残疾、身体功能、心理健康和社会功能。
结果
招募了25名参与者（中位年龄：32.8岁，76%为女性）。参与率（60%）、留存率（T1时为84%，T2时为72%）和项目依从性（教育课程为76%，运动课程为74%）支持了可行性。定性访谈（n = 9）支持了对可行性和可接受性的强烈认知。未发生归因于CaRE-AYA的严重不良事件（≥3级）。
结论
结果表明CaRE-AYA是可行、可接受且安全的。需要进行一项随机对照试验来确定其有效性。
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