Keshavarz Samaneh, Alavi Cyrus Emir, Aghayan Hamidreza, Jafari-Shakib Reza, Vojoudi Elham
School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Anesthesiology, Neuroscience Research Center, Avicenna University Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Stem Cell Rev Rep. 2025 Apr 15. doi: 10.1007/s12015-025-10882-z.
Regenerative medicine represents a transformative approach to treating nucleus pulposus degeneration and offers hope for patients suffering from chronic low back pain due to disc degeneration. By focusing on restoring the natural structure and function of the nucleus pulposus rather than merely alleviating symptoms, these innovative therapies hold the potential to significantly improve patient outcomes. As research continues to advance in this field, we may soon witness a paradigm shift in how we approach spinal health and degenerative disc disease. The main purpose of this review is to provide an overview of the various regenerative approaches that target the restoration of the nucleus pulposus, a primary site for initiation of intervertebral disc degeneration.
再生医学是一种治疗髓核退变的变革性方法,为因椎间盘退变而患有慢性腰痛的患者带来了希望。通过专注于恢复髓核的自然结构和功能,而不仅仅是缓解症状,这些创新疗法有可能显著改善患者的治疗效果。随着该领域研究的不断推进,我们可能很快会看到在脊柱健康和椎间盘退变疾病的治疗方法上发生范式转变。本综述的主要目的是概述各种旨在恢复髓核的再生方法,髓核是椎间盘退变起始的主要部位。