Artificial Intelligence Software to Accelerate Screening for Living Systematic Reviews.

Systematic and meta-analytic reviews provide gold-standard evidence but are static and outdate quickly. Here we provide performance data on a new software platform, LitQuest, that uses artificial intelligence technologies to (1) accelerate screening of titles and abstracts from library literature searches, and (2) provide a software solution for enabling living systematic reviews by maintaining a saved AI algorithm for updated searches. Performance testing was based on LitQuest data from seven systematic reviews. LitQuest efficiency was estimated as the proportion (%) of the total yield of an initial literature search (titles/abstracts) that needed human screening prior to reaching the in-built stop threshold. LitQuest algorithm performance was measured as work saved over sampling (WSS) for a certain recall. LitQuest accuracy was estimated as the proportion of incorrectly classified papers in the rejected pool, as determined by two independent human raters. On average, around 36% of the total yield of a literature search needed to be human screened prior to reaching the stop-point. However, this ranged from 22 to 53% depending on the complexity of language structure across papers included in specific reviews. Accuracy was 99% at an interrater reliability of 95%, and 0% of titles/abstracts were incorrectly assigned. Findings suggest that LitQuest can be a cost-effective and time-efficient solution to supporting living systematic reviews, particularly for rapidly developing areas of science. Further development of LitQuest is planned, including facilitated full-text data extraction and community-of-practice access to living systematic review findings.