天然多酚作为衰老及与年龄相关疾病的新型干预手段：探索其功效、作用机制及对未来研究的意义。

Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research.

作者信息

Wu Wenze, Mi Yan, Meng Qingqi, Li Ning, Li Wei, Wang Pu, Hou Yue

机构信息

Liaoning Key Laboratory of Bioresource Research and Development, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, College of Life and Health Sciences, Northeastern University, Shenyang 110169, China.

Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 117004, China.

出版信息

Chin Herb Med. 2024 Sep 3;17(2):279-291. doi: 10.1016/j.chmed.2024.09.001. eCollection 2025 Apr.

DOI:10.1016/j.chmed.2024.09.001

PMID:40256718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12009074/

Abstract

Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple mechanisms. Nanotechnology, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and age-related diseases.

摘要

天然多酚是一类在传统中药中广泛存在的成分，近年来已被证明可延缓或预防衰老及与年龄相关疾病的发生。据我们所知，尚未对天然多酚在衰老及与衰老相关疾病方面的研究进行过广泛综述。在本文中，我们综述了天然多酚在衰老及常见与年龄相关疾病方面的最新进展，以及当前提高天然多酚生物利用度的技术方法。结果表明，天然多酚有潜力通过多种机制预防或治疗衰老及常见与年龄相关疾病。纳米技术、结构修饰和基质处理可为天然多酚预防或治疗衰老及与年龄相关疾病的开发提供有力的技术支持。总之，天然多酚在预防和治疗衰老及与年龄相关疾病方面具有重要潜力。