Kaye Alan D, Tong Victoria T, Islam Rahib K, Nguyen Ivan, Abbott Brennan M, Patel Chandni, Muiznieks Luke, Bass Daniel, Hirsch Jon D, Urman Richard D, Ahmadzadeh Shahab, Allampalli Varsha, Shekoohi Sahar
Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
School of Medicine, LSU Health Sciences Center New Orleans, 1901 Gravier Street, New Orleans, LA, 70112, USA.
Curr Pain Headache Rep. 2025 Apr 23;29(1):78. doi: 10.1007/s11916-025-01391-2.
The present investigation evaluated the use of opioids for postoperative pain relief in spinal surgery patients.
Pain management is a crucial component of postoperative care that greatly impacts patient outcomes. Postoperative pain management has been shown to allow for earlier mobility, discharge, and return to normal life. Opioids are the standard treatment for postoperative pharmacologic pain relief, but they are associated with the same adverse effects that pain management strives to mitigate. Opioids are associated with a large side effect profile, including a higher risk of various postoperative complications. Opioids are potentially highly addictive and postoperative use is associated with dependence, tolerance, and the current opioid epidemic. Some studies indicate that there are similar surgical outcomes amongst patients independent of whether opioids were prescribed opioids for pain relief.
Opioids should only be recommended for postoperative pain management under strict guidance and supervision from physicians. All 50 states have acute pain guidelines in place limiting opioid prescribing. One of the strategies of reducing postoperative opioid consumption is the emphasis on opioid alternatives that should be actively considered and explored prior to resorting to opioids. There are pharmacological and non-pharmacological options available for pain relief that can provide similar levels of analgesia as prescription opioid without unwanted effects such as tolerance and dependency. Proper assessment of patient history and risk factors can aid physicians in tailoring a pain management regimen that is appropriate for each individual patient. More research into efficacy and safety of alternative treatments to opioids is warranted.
本研究评估了阿片类药物在脊柱手术患者术后疼痛缓解中的应用。
疼痛管理是术后护理的关键组成部分,对患者的预后有重大影响。术后疼痛管理已被证明可以使患者更早活动、出院并恢复正常生活。阿片类药物是术后药物止痛的标准治疗方法,但它们会带来疼痛管理旨在减轻的相同不良反应。阿片类药物有一系列较大的副作用,包括各种术后并发症的风险更高。阿片类药物具有潜在的高度成瘾性,术后使用与药物依赖、耐受性以及当前的阿片类药物流行有关。一些研究表明,无论是否开具阿片类药物用于止痛,患者的手术结局相似。
仅应在医生的严格指导和监督下推荐阿片类药物用于术后疼痛管理。所有50个州都制定了限制阿片类药物处方的急性疼痛指南。减少术后阿片类药物使用量的策略之一是强调在使用阿片类药物之前应积极考虑和探索阿片类药物的替代方法。有多种药物和非药物止痛选择,它们可以提供与处方阿片类药物相似的镇痛水平,且不会产生耐受性和依赖性等不良影响。对患者病史和风险因素的正确评估有助于医生制定适合每个患者的疼痛管理方案。有必要对阿片类药物替代治疗的疗效和安全性进行更多研究。