上皮-间质转化驱动癌症基因组不稳定。

Epithelial-to-mesenchymal transition drives cancer genomic instability.

作者信息

Carstens Julienne L, Lovisa Sara

机构信息

Department of Medicine, Division of Hematology & Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.

O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

J Exp Clin Cancer Res. 2025 Apr 30;44(1):135. doi: 10.1186/s13046-025-03402-x.

DOI:10.1186/s13046-025-03402-x

PMID:40301945

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12042499/

Abstract

Epithelial-to-Mesenchymal Transition (EMT) is a form of embryonic cell plasticity reactivated in adult cells during injury and cancer. A recent study by Perelli et al. demonstrates that EMT confers an evolutionary advantage to tumors by inducing chromosomal instability, structural genomic rearrangements and chromothripsis, thus favoring the emergence of high-fitness malignant clones.

摘要

上皮-间质转化（EMT）是一种胚胎细胞可塑性形式，在损伤和癌症发生过程中会在成体细胞中重新激活。佩雷利等人最近的一项研究表明，EMT通过诱导染色体不稳定性、结构基因组重排和染色体碎裂，赋予肿瘤一种进化优势，从而有利于高适应性恶性克隆的出现。