Selya Arielle, Kim Sooyong, Shiffman Saul, Goldenson Nicholas
PinneyAssociates, Inc, Pittsburgh, PA, USA.
JUUL Labs, Inc, Washington, DC, USA.
Harm Reduct J. 2025 May 2;22(1):71. doi: 10.1186/s12954-025-01231-x.
Adults who smoke cigarettes can benefit from switching completely to electronic nicotine delivery systems (ENDS). Research is needed to examine longer-term switching trajectories beyond one year of follow-up.
This analysis of a previously-described longitudinal cohort study of adults who smoke and purchased JUUL focused on N = 11,153 who completed the 12-month (12 M) follow-up and ≥ 1 of 4 surveys in the second year (Y2; at 15, 18, 21, and 24 months). Outcomes were repeated point prevalence of product use over the past-30-days (P30D) at each Y2 follow-up: repeated point prevalence-switching (i.e., no P30D smoking at any available Y2 follow-ups), repeated point prevalence-smoking, or varying status. Associations between product use status at 12M (switched, exclusive smoking, or dual used) and Y2 product use patterns were examined.
Most adults who smoked at baseline and were switched at 12 M reported repeated point prevalence-switching over Y2 (69.5%); repeated point prevalence-smoking was rare (6.2%). In contrast, > 50% of those who were smoking at 12 M (exclusively or with ENDS [JUUL or other brand]) persistently smoked over Y2. Supplementary analyses showed that among adults who exclusively used ENDS at 12 M, those who used ENDS daily were more likely to persistently switch over Y2; similarly, among adults who smoked at 12 M (either exclusively or dual-use with ENDS) those who smoked nondaily were more likely to persistently switch over Y2. Over half of adults who dual used at both 12 M and 24 M substantially reduced (i.e., by 50%+) their baseline cigarette consumption.
For the majority of participants, product use status at 12 M was consistent with use patterns in the second year: most adults who smoked at baseline and were switched at 12 M reported repeated point prevalence-switching over Y2, while any smoking at 12 M- especially daily smoking- was usually followed by repeated point prevalence-smoking. These findings indicate that switching and smoking behavior is generally maintained and remains stable one year after purchasing ENDS.
吸烟的成年人完全改用电子尼古丁传送系统(ENDS)会受益。需要开展研究来考察随访一年以上的长期转换轨迹。
这项对之前描述的吸烟且购买了JUUL的成年人纵向队列研究的分析聚焦于完成12个月(12M)随访且在第二年(Y2;第15、18、21和24个月)完成4次调查中至少1次调查的N = 11,153名参与者。结局是每次Y2随访时过去30天(P30D)产品使用的重复点患病率:重复点患病率转换(即在任何可用的Y2随访中无P30D吸烟)、重复点患病率吸烟或状态变化。考察了12M时的产品使用状态(已转换、仅吸烟或双重使用)与Y2产品使用模式之间的关联。
大多数在基线时吸烟且在12M时转换的成年人报告在Y2期间重复点患病率转换(69.5%);重复点患病率吸烟很少见(6.2%)。相比之下,12M时吸烟的人(仅吸烟或与ENDS [JUUL或其他品牌]一起吸烟)中超过50%在Y2期间持续吸烟。补充分析表明,在12M时仅使用ENDS的成年人中,每天使用ENDS的人在Y2期间更有可能持续转换;同样,在12M时吸烟的成年人(仅吸烟或与ENDS双重使用)中,非每天吸烟的人在Y2期间更有可能持续转换。在12M和24M时都双重使用的成年人中,超过一半的人将其基线香烟消费量大幅减少(即减少50%以上)。
对于大多数参与者而言,12M时的产品使用状态与第二年的使用模式一致:大多数在基线时吸烟且在12M时转换的成年人报告在Y2期间重复点患病率转换,而12M时的任何吸烟——尤其是每天吸烟——之后通常是重复点患病率吸烟。这些发现表明,在购买ENDS一年后,转换和吸烟行为总体上得以维持且保持稳定。