迈向单细胞分辨率下的人类和小鼠脂肪组织共识图谱。
Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.
作者信息
Loft Anne, Emont Margo P, Weinstock Ada, Divoux Adeline, Ghosh Adhideb, Wagner Allon, Hertzel Ann V, Maniyadath Babukrishna, Deplancke Bart, Liu Boxiang, Scheele Camilla, Lumeng Carey, Ding Changhai, Ma Chenkai, Wolfrum Christian, Strieder-Barboza Clarissa, Li Congru, Truong Danh D, Bernlohr David A, Stener-Victorin Elisabet, Kershaw Erin E, Yeger-Lotem Esti, Shamsi Farnaz, Hui Hannah X, Camara Henrique, Zhong Jiawei, Kalucka Joanna, Ludwig Joseph A, Semon Julie A, Jalkanen Jutta, Whytock Katie L, Dumont Kyle D, Sparks Lauren M, Muir Lindsey A, Fang Lingzhao, Massier Lucas, Saraiva Luis R, Beyer Marc D, Jeschke Marc G, Mori Marcelo A, Boroni Mariana, Walsh Martin J, Patti Mary-Elizabeth, Lynes Matthew D, Blüher Matthias, Rydén Mikael, Hamda Natnael, Solimini Nicole L, Mejhert Niklas, Gao Peng, Gupta Rana K, Murphy Rinki, Pirouzpanah Saeed, Corvera Silvia, Tang Su'an, Das Swapan K, Schmidt Søren F, Zhang Tao, Nelson Theodore M, O'Sullivan Timothy E, Efthymiou Vissarion, Wang Wenjing, Tong Yihan, Tseng Yu-Hua, Mandrup Susanne, Rosen Evan D
机构信息
Center for Functional Genomics and Tissue Plasticity (ATLAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Odense, Denmark.
Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL, USA.
出版信息
Nat Metab. 2025 May 13. doi: 10.1038/s42255-025-01296-9.
Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.
脂肪组织（AT）是一种复杂的结缔组织，其中脂肪细胞的相对比例较高，脂肪细胞是能够将脂质储存在大液滴中的特化细胞。AT存在于全身多个离散的储存部位，是多余热量的主要储存库。此外，AT在绝缘、免疫和代谢稳态调节等多种功能中发挥着重要作用。人类细胞图谱脂肪生物网络的建立是为了支持人类AT单细胞图谱的生成，以及开发统一的细胞注释方法和共识。在这里，我们提供了这个生物网络的第一份路线图，包括我们建议的人类和小鼠细胞注释，目的是描述该领域的现状，并为AT单细胞数据的生成、分析、解释和呈现提供指导。
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