and evaluation of diazenyl compounds as anti-bacterial agents.

AIM

The diazenyls are interesting scaffold in medicinal chemistry displaying a wide range of pharmacological activities including anti-microbial, anti-cancer, anti-inflammatory, and analgesic-antipyretic, among others. These diverse attributes have reinitiated the interest of the researchers in them. Studies suggest that incorporating heterocyclic ring system into diazenyl scaffold helps to improve the biological property of the drug-like substances. The present study aims to synthesize novel diazinyl-triazole adducts, with an intent to obtain compounds with enhanced anti-bacterial potential.

MATERIALS AND METHODS

All synthesized compounds were characterized using physicochemical methods and spectroscopic techniques. The compounds were evaluated against two Gram-positive and two Gram-negative bacterial strains, demonstrating good to moderate efficacy. prediction study was also carried out for the synthesized series of compounds.

RESULTS AND CONCLUSION

The molecular docking data are aligned with the experimental results. The ADMET predictions suggested the compounds are both efficacious and safe. The study presents new compounds as potential anti-bacterial agents with desirable pharmacological profile.