OXA-101和OXA-573在广泛耐药/泛耐药（XDR/PDR）菌对头孢他啶-阿维巴坦耐药中的作用
The Role of OXA-101 and OXA-573 in Extensively Drug-Resistant/ Pan Drug-Resistant (XDR/PDR) Resistance to Ceftazidime-Avibactam.
作者信息
Kang Yixin, Cui Junchang
机构信息
Nankai University, Tianjin, People's Republic of China.
College of Pulmonary & Critical Care Medicine, The Eighth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
出版信息
Infect Drug Resist. 2025 May 16;18:2547-2555. doi: 10.2147/IDR.S506452. eCollection 2025.
OBJECTIVE
To explore the association of the resistance of extensively drug-resistant/ pan-drug-resistant (XDR/PDR-PA) to ceftazidime-avibactam (CZA) with various class D β-lactamase genes.
METHODS
Twofold dilution was used to determine the minimum inhibitory concentration (MIC) of CZA against XDR/PDR-PA. Whole genome sequencing and bioinformatics analysis were used to determine the drug-resistant genes of each isolate. Pearson correlation coefficient and statistical analysis were used to assess the association of the resistance of XDR/PDR-PA to CZA and various class D β-lactamase genes.
RESULTS
ST244 was the predominant type (34/68, 50%) among the 68 XDR/PDR-PA strains. Subsequently, ST357 was the second most prevalent type (5/68, 7.4%) strain. OXA-101 and OXA-573 genes were associated with resistance to CZA (-value was 0.029 and 0.021, respectively) in the 68 XDR/PDR-PA isolates tested.
CONCLUSION
Our work found that OXA-101 and OXA-847 play a role in XDR/PDR-PA resistance to CZA.
目的
探讨广泛耐药/泛耐药铜绿假单胞菌（XDR/PDR-PA）对头孢他啶-阿维巴坦（CZA）的耐药性与各种D类β-内酰胺酶基因之间的关联。
方法
采用二倍稀释法测定CZA对XDR/PDR-PA的最低抑菌浓度（MIC）。运用全基因组测序和生物信息学分析确定各分离株的耐药基因。采用Pearson相关系数和统计分析评估XDR/PDR-PA对CZA的耐药性与各种D类β-内酰胺酶基因之间的关联。
结果
在68株XDR/PDR-PA菌株中，ST244是主要类型（34/68，50%）。其次，ST357是第二常见类型（5/68，7.4%）的菌株。在测试的68株XDR/PDR-PA分离株中，OXA-101和OXA-573基因与对CZA的耐药性相关（-值分别为0.029和0.021）。
结论
我们的研究发现OXA-101和OXA-847在XDR/PDR-PA对CZA的耐药性中起作用。
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