精准医学与疾病、诊断及转化中的人类蛋白质组：现状与未来展望
Precision Medicine and the Human Proteome in Disease, Diagnostics and Translation: Current Status and Future Prospects.
作者信息
Qoronfleh M Walid
机构信息
Healthcare Research & Policy Division, Q3 Research Institute (QRI), 7227 Rachel Drive, Ypsilanti, MI 48917, USA.
Healix Lab, Al Khuwair South, Muscat 123, Oman.
出版信息
Biomedicines. 2025 May 7;13(5):1130. doi: 10.3390/biomedicines13051130.
The human proteome-the entire collection of proteins expressed by the human genome-represents a dynamic and intricate landscape of biological function. Proteins are the workhorses of the body, driving processes from cellular communication to immune defense, and their alterations underpin many diseases. Understanding the proteome has become a cornerstone of modern biomedical research, offering insights into disease mechanisms, diagnostic tools, and personalized treatments through precision medicine. This commentary explores the current state of human proteome research; its applications in disease understanding, diagnostics, and therapeutic advancements; and the exciting prospects that lie ahead.
人类蛋白质组——由人类基因组表达的所有蛋白质的集合——代表了一个动态且复杂的生物功能图景。蛋白质是身体的“主力军”，推动着从细胞通讯到免疫防御等各种生理过程，其变化是许多疾病的基础。了解蛋白质组已成为现代生物医学研究的基石，通过精准医学为疾病机制、诊断工具和个性化治疗提供见解。本评论探讨了人类蛋白质组研究的现状；其在疾病理解、诊断和治疗进展方面的应用；以及未来令人兴奋的前景。
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