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Editing epigenetic age.

作者信息

Heijmans Bastiaan T

机构信息

Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Nat Aging. 2025 Jun 2. doi: 10.1038/s43587-025-00893-3.

DOI:10.1038/s43587-025-00893-3

PMID:40456957

Abstract

摘要

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本文引用的文献

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape.

Nat Aging. 2025 Mar 24. doi: 10.1038/s43587-025-00841-1.

How quickly are you ageing? What molecular 'clocks' can tell you about your health.

Nature. 2025 Feb;638(8052):874-876. doi: 10.1038/d41586-025-00566-6.

Quantifying stochasticity in the aging DNA methylome.

Nat Aging. 2024 Jun;4(6):755-758. doi: 10.1038/s43587-024-00634-y.

Universal DNA methylation age across mammalian tissues.

Nat Aging. 2023 Sep;3(9):1144-1166. doi: 10.1038/s43587-023-00462-6. Epub 2023 Aug 10.

Refining epigenetic prediction of chronological and biological age.

Genome Med. 2023 Feb 28;15(1):12. doi: 10.1186/s13073-023-01161-y.

Hallmarks of aging: An expanding universe.

Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression.

Genome Biol. 2022 Jan 14;23(1):24. doi: 10.1186/s13059-021-02585-8.

BANP opens chromatin and activates CpG-island-regulated genes.

Nature. 2021 Aug;596(7870):133-137. doi: 10.1038/s41586-021-03689-8. Epub 2021 Jul 7.

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.

Genome Biol. 2020 Aug 28;21(1):220. doi: 10.1186/s13059-020-02114-z.

DNA methylation aging clocks: challenges and recommendations.

Genome Biol. 2019 Nov 25;20(1):249. doi: 10.1186/s13059-019-1824-y.

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相似文献

Editing epigenetic age.

Nat Aging. 2025 Jun 2. doi: 10.1038/s43587-025-00893-3.

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape.

Nat Aging. 2025 Mar 24. doi: 10.1038/s43587-025-00841-1.

Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy.

Clin Immunol. 2018 Nov;196:49-58. doi: 10.1016/j.clim.2018.02.001. Epub 2018 Feb 6.

Advances of epigenetic editing.

Curr Opin Chem Biol. 2020 Aug;57:75-81. doi: 10.1016/j.cbpa.2020.04.020. Epub 2020 Jun 30.

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Genes Genomics. 2022 Mar;44(3):307-315. doi: 10.1007/s13258-021-01199-5. Epub 2022 Jan 9.

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Subcell Biochem. 2025;108:111-190. doi: 10.1007/978-3-031-75980-2_4.

CRISPR/Cas mediated epigenome editing for cancer therapy.

Semin Cancer Biol. 2022 Aug;83:570-583. doi: 10.1016/j.semcancer.2020.12.018. Epub 2021 Jan 6.

Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing.

CRISPR J. 2022 Apr;5(2):203-212. doi: 10.1089/crispr.2021.0094. Epub 2022 Mar 22.

Precision epigenetic editing: Technological advances, enduring challenges, and therapeutic applications.

Cell Chem Biol. 2024 Aug 6. doi: 10.1016/j.chembiol.2024.07.007.

Correction of Heritable Epigenetic Defects Using Editing Tools.

Int J Mol Sci. 2021 Apr 12;22(8):3966. doi: 10.3390/ijms22083966.

本文引用的文献

Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape.

Nat Aging. 2025 Mar 24. doi: 10.1038/s43587-025-00841-1.

How quickly are you ageing? What molecular 'clocks' can tell you about your health.

Nature. 2025 Feb;638(8052):874-876. doi: 10.1038/d41586-025-00566-6.

Quantifying stochasticity in the aging DNA methylome.

Nat Aging. 2024 Jun;4(6):755-758. doi: 10.1038/s43587-024-00634-y.

Universal DNA methylation age across mammalian tissues.

Nat Aging. 2023 Sep;3(9):1144-1166. doi: 10.1038/s43587-023-00462-6. Epub 2023 Aug 10.

Refining epigenetic prediction of chronological and biological age.

Genome Med. 2023 Feb 28;15(1):12. doi: 10.1186/s13073-023-01161-y.

Hallmarks of aging: An expanding universe.

Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression.

Genome Biol. 2022 Jan 14;23(1):24. doi: 10.1186/s13059-021-02585-8.

BANP opens chromatin and activates CpG-island-regulated genes.

Nature. 2021 Aug;596(7870):133-137. doi: 10.1038/s41586-021-03689-8. Epub 2021 Jul 7.

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference.

Genome Biol. 2020 Aug 28;21(1):220. doi: 10.1186/s13059-020-02114-z.

DNA methylation aging clocks: challenges and recommendations.

Genome Biol. 2019 Nov 25;20(1):249. doi: 10.1186/s13059-019-1824-y.