孕期感染新冠病毒的母亲所生儿童头两年的生长情况：一项队列研究
Growth in the first two years in children born to mothers infected with COVID-19 during pregnancy: a cohort study.
作者信息
Biglari Habibe Nejad, Ahmadi Atefeh, Alidousti Katayoun, Pouredalati Malihe, Kalantari Forouzandeh, Kargar Effat, Tezerji Farzaneh Salajegheh, Dadshahi Sahebeh, Afshar Parya Jangipour, Sharifi Hamid, Ghazanfarpour Masumeh, Janipour Fatemeh, Heidari Fariba
机构信息
Neuroscience Research Center, Institute of neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Reproductive and family health research Center, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
BMC Pediatr. 2025 Jun 3;25(1):448. doi: 10.1186/s12887-025-05663-z.
INTRODUCTION
Because the impact of COVID-19 on the growth of infants whose mothers were infected with this virus during pregnancy is unclear, this study investigated the effect of mothers' infection with this virus during pregnancy on their infant's growth during the first two years of life.
METHOD
In this prospective cohort study, the available information from 697 mothers referring to Iran's health care centers for pregnancy and breastfeeding care was used to compare the growth of 367 children born to mothers infected with COVID-19 during pregnancy with that of 330 children born to mothers who were not infected and not exposed to COVID-19 during pregnancy. Their growth was evaluated for two years.
RESULTS
Concerning the weight, height, and head circumference 6 months, 12 months, and 24 months after birth, although the values obtained in the exposed group were slightly higher than the non-exposed group, no statistically significant difference was observed (P > 0.05). Comparing the exposed group's growth indices (weight, height, and head circumference) based on whether the mother was infected with COVID-19 during the first, second, or third trimester showed no significant difference (P > 0.05). The birth height of the babies whose mothers infected with COVID-19 in the first and second trimesters of pregnancy was slightly lower than those whose mothers were infected in the third trimester (P = 0.019). Children in the exposed group weighed 76.61 g more than those in the non-exposed group (P = 0.018).
CONCLUSION
More long-term studies in different populations about growth of children are needed to generalized the findings.
CLINICAL TRIAL NUMBER
Not applicable (A cohort study).
引言
由于新冠病毒病（COVID-19）对孕期感染该病毒的母亲所生婴儿生长发育的影响尚不清楚，本研究调查了母亲孕期感染此病毒对其婴儿出生后头两年生长发育的影响。
方法
在这项前瞻性队列研究中，利用来自伊朗医疗保健中心的697名寻求孕期和哺乳期护理的母亲的现有信息，比较367名母亲孕期感染COVID-19所生儿童与330名母亲孕期未感染且未接触COVID-19所生儿童的生长发育情况。对他们的生长发育情况进行了两年的评估。
结果
关于出生后6个月、12个月和24个月时的体重、身高和头围，尽管暴露组获得的值略高于非暴露组，但未观察到统计学上的显著差异（P>0.05）。根据母亲在孕早期、孕中期或孕晚期是否感染COVID-19比较暴露组的生长指标（体重、身高和头围），未发现显著差异（P>0.05）。母亲在孕早期和孕中期感染COVID-19的婴儿出生时的身高略低于母亲在孕晚期感染的婴儿（P=0.019）。暴露组儿童比非暴露组儿童重76.61克（P=0.018）。
结论
需要在不同人群中开展更多关于儿童生长发育的长期研究，以便推广这些研究结果。
临床试验编号
不适用（队列研究）
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