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关注一个被遗忘的年龄组:关于迟发性双相情感障碍的讨论

Bringing Attention to a Forgotten Age Group: A Discussion on Late-Onset Bipolar Disorder.

作者信息

Savant Sanyukta, Chirumamilla Krishna Geeth, Leontieva Luba

机构信息

Medicine, Independent Research, Somerville, USA.

Psychiatry, State University of New York Upstate Medical University, Syracuse, USA.

出版信息

Cureus. 2025 May 11;17(5):e83904. doi: 10.7759/cureus.83904. eCollection 2025 May.

Abstract

Affecting millions worldwide, bipolar disorder is a chronic condition most commonly diagnosed before the age of 50. However, diagnosing bipolar disorder beyond this age bracket presents unique challenges and is referred to as late-onset bipolar disorder. Due to the limited availability of data, this diagnosis remains complex. Although several efforts have been made to understand the impact of age of onset and neurologic etiologies on the condition, extensive research on this subject is unavailable, which will definitely facilitate enhancing services to this group. We present the case of a 75-year-old male with a past psychiatric history of late-onset bipolar disorder, anxiety, depression, and a historical diagnosis of obsessive-compulsive personality disorder. He was first diagnosed with bipolar I disorder in his 60s following a manic episode by his primary care physician. His condition was subsequently managed with lamotrigine 100 mg daily and olanzapine 2.5 mg daily. No prior hospitalizations for mania or any other psychiatric etiology were noted. During this admission to the hospital, the patient presented with symptoms of mania and paranoia and was difficult to redirect. He exhibited signs of distractibility, tangentiality, pressured speech with increased pace, flight of ideas, and reduced need for sleep. This case helps highlight the variability in presentation of bipolar disorder in older adults, unexplained by other organic causes, and its successful management. It also instigates a discussion about limited data and guidelines in this age group.

摘要

双相情感障碍影响着全球数百万人,是一种慢性疾病,最常在50岁之前被诊断出来。然而,在这个年龄范围之外诊断双相情感障碍存在独特的挑战,被称为迟发性双相情感障碍。由于数据有限,这种诊断仍然很复杂。尽管已经做出了一些努力来了解发病年龄和神经病因对该疾病的影响,但关于这个主题的广泛研究仍然缺乏,这肯定有助于加强对这一群体的服务。我们介绍了一名75岁男性的病例,他有迟发性双相情感障碍、焦虑、抑郁的既往精神病史,以及既往强迫症人格障碍的诊断。他在60多岁时因一次躁狂发作被初级保健医生首次诊断为双相I型障碍。他的病情随后通过每天服用100毫克拉莫三嗪和2.5毫克奥氮平进行控制。没有记录到之前因躁狂或任何其他精神病因住院的情况。在这次住院期间,患者出现了躁狂和妄想症状,难以被转移注意力。他表现出注意力分散、离题、语速加快的急促言语、思维奔逸和睡眠需求减少的迹象。这个病例有助于突出老年人双相情感障碍表现的变异性,这种变异性无法用其他器质性原因解释,以及其成功的治疗。它还引发了关于这个年龄组数据和指南有限的讨论。

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