住院 COVID-19 孕妇与非孕妇临床及实验室特征的差异。
Differences in Clinical and Laboratory Features of Pregnant and Non-Pregnant Female with Hospitalized COVID-19.
作者信息
Ilyas Muhana F, Novika Revi G H, Triniputri Winastari Y, Pradipta I M E W, Ksamawati Ni W P S, Wahidah Nurul J, Hartono Hartono, Sumarno Lanjar
机构信息
Medical Doctor Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
出版信息
Iran J Nurs Midwifery Res. 2025 May 8;30(3):322-331. doi: 10.4103/ijnmr.ijnmr_86_23. eCollection 2025 May-Jun.
BACKGROUND
The impact of COVID-19 on vulnerable populations, including pregnant female, is critical due to higher risks and potential complications. This study aims to compare the clinical and laboratory features of COVID-19 between pregnant and non-pregnant female.
MATERIALS AND METHODS
This retrospective cohort study included 245 COVID-19 patients admitted to Universitas Sabellas Maret (UNS) Hospital, Indonesia, from March 2020 to May 2022. Among them, 72 were pregnant, and 173 were non-pregnant. Data on demographics, clinical presentations, and laboratory findings were collected from medical records. Statistical analysis utilized Chi-square or Fisher exact tests, Mann-Whitney or independent t-tests, and multiple linear regression.
RESULTS
No significant demographic differences were found, except in hospitalization status. Clinically, pregnant female had a higher prevalence of symptoms such as cough ( = 0.002), fatigue ( = 0.025), and shortness of breath ( = 0.035), with no differences in other symptoms or length of stay. Laboratory findings indicated significant differences in White Cell Count (WCC), Absolute Lymphocyte Count (ALC), High Fluorescence Lymphocyte Count (HFLC), lymphocyte percentage, neutrophil percentage, Neutrophil Lymphocyte Ratio (NLR), Red Cell Count (RCC), Hemoglobin (Hb), Hematocrit (Hct), Platelet Count (PC), Prothrombin Time (PT), International Normalized Ratio (INR), D-Dimer, and Sodium ( values < 0.05). Multivariate analysis identified WCC, lymphocyte percentage, HFLC, neutrophil percentage, PT, INR, D-Dimer, Creatinine, and Potassium as significant predictors of length of stay (R²adj = 0.874, F = 17.979, < 0.001).
CONCLUSIONS
Pregnant female with COVID-19 exhibited distinct laboratory profiles compared to non-pregnant female. These findings highlight the need for tailored management strategies for COVID-19 in pregnant patients and provide a foundation for further research.
背景
由于风险较高及潜在并发症，2019冠状病毒病（COVID-19）对包括孕妇在内的弱势群体的影响至关重要。本研究旨在比较孕妇和非孕妇COVID-19的临床和实验室特征。
材料与方法
这项回顾性队列研究纳入了2020年3月至2022年5月期间入住印度尼西亚三宝垄玛拉特大学（UNS）医院的245例COVID-19患者。其中，72例为孕妇，173例为非孕妇。从病历中收集人口统计学、临床表现和实验室检查结果的数据。统计分析采用卡方检验或Fisher精确检验、Mann-Whitney检验或独立t检验以及多元线性回归。
结果
除住院状态外，未发现显著的人口统计学差异。临床上，孕妇咳嗽（P = 0.002）、疲劳（P = 0.025）和呼吸急促（P = 0.035）等症状的患病率较高，其他症状或住院时间无差异。实验室检查结果表明，白细胞计数（WCC）、绝对淋巴细胞计数（ALC）、高荧光淋巴细胞计数（HFLC）、淋巴细胞百分比、中性粒细胞百分比、中性粒细胞淋巴细胞比值（NLR）、红细胞计数（RCC）、血红蛋白（Hb）、血细胞比容（Hct）、血小板计数（PC）、凝血酶原时间（PT）、国际标准化比值（INR）、D-二聚体和钠存在显著差异（P值<0.05）。多因素分析确定WCC、淋巴细胞百分比、HFLC、中性粒细胞百分比、PT、INR、D-二聚体、肌酐和钾是住院时间的显著预测因素（调整后R² = 0.874，F = 17.979，P < 0.001）。
结论
与非孕妇相比，感染COVID-19的孕妇表现出不同的实验室特征。这些发现凸显了针对孕妇COVID-19制定个性化管理策略的必要性，并为进一步研究提供了基础。
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