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微马达与集体(生物)传感:检测背后的资产。

Micromotors Meet Collective (Bio)sensing: The Asset Behind the Assay.

作者信息

Escarpa Alberto, Jurado-Sánchez Beatriz

机构信息

Department of Analytical Chemistry, Physical Chemistry, and Chemical Engineering, Universidad de Alcala, Alcala de Henares, E-28802 Madrid, Spain.

Chemical Research Institute "Andres M. del Rio", Universidad de Alcala, E-28802 Madrid, Spain.

出版信息

Anal Chem. 2025 Jul 1;97(25):12913-12924. doi: 10.1021/acs.analchem.5c00619. Epub 2025 Jun 19.

Abstract

Micromotors are microscale devices with enormous potential for analytical (bio)sensing due to autonomous motion capabilities in extremely small sample volumes or for guided detection in localized hard-to-reach areas. These unique features enable dynamic interactions with the analytes, offering considerable promise in microscale environments and opening new avenues for on-the-fly (bio)sensing strategies. By selecting and discussing the ideas and findings behind pioneering works, we offer our perspective on the current state of the art in the field of (bio)sensing approaches based on the micromotors classified according to their detection principle: motion-based, optical, and electrochemical sensing. We will also draw attention to current challenges and opportunities that have not yet been fully explored, in a landscape that is as exciting as it is changing.

摘要

微马达是一种微型设备,因其在极少量样品中具备自主运动能力,或可用于在局部难以触及的区域进行引导检测,因而在分析(生物)传感方面具有巨大潜力。这些独特特性使得微马达能够与分析物进行动态相互作用,在微观环境中展现出可观的前景,并为即时(生物)传感策略开辟了新途径。通过挑选并讨论开创性研究背后的思路和发现,我们基于根据检测原理分类的微马达,对(生物)传感方法领域的当前技术水平发表我们的观点:基于运动的传感、光学传感和电化学传感。在这个既令人兴奋又不断变化的领域中,我们还将关注尚未得到充分探索的当前挑战和机遇。

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