Luis Israel, Gutierrez-Farewik Elena M
KTH MoveAbility, Department of Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden.
KTH MoveAbility, Department of Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Gait Posture. 2025 Sep;121:315-324. doi: 10.1016/j.gaitpost.2025.06.006. Epub 2025 Jun 10.
Musculoskeletal simulations can guide the search for optimal strategies to assist motion and reveal causal relationships between assistive moments and muscle dynamics. Assistive devices such as exoskeletons can complement muscle forces based on various aims, such as minimum muscle effort or maximal force distribution. In this study, we present a simulation framework to systematically identify optimal assistance, formulated as a bilevel optimization in a single inverse simulation scheme that seeks optimal assistive moments that fulfill different assistive device aims.
Bilevel optimization of assistive moment was structured as an inner optimization problem to solve the muscle redundancy problem nested within an outer optimization problem that executes the inner problem iteratively, seeking an assistive moment that best satisfies the assistive aim. We used this framework to predict optimal ankle plantarflexion, hip extension, hip flexion, and hip abduction assistance, for three different aims: minimal muscle activations, minimal metabolic rates, and minimal muscle moments. Experimental data from twelve participants walking at preferred speed were used in this study.
We found that the optimal moment trajectory is unique for a given assistive aim; i.e., the assistive aim matters. Differences in the assistive trajectories are explained at the muscle level, and as active and passive force contributions to the net muscle moments and muscle mechanical work. Interestingly, the assistive moments for minimal metabolic rates predicted an assistance period and peak timing similar to those reported from experimental studies.
Our findings suggest that explicit assistive aim formulation is required to investigate human-device interaction under optimal assistance.
肌肉骨骼模拟可以指导寻找辅助运动的最佳策略,并揭示辅助力矩与肌肉动力学之间的因果关系。诸如外骨骼之类的辅助设备可以根据各种目标(例如最小化肌肉用力或最大化力分布)来补充肌肉力量。在本研究中,我们提出了一个模拟框架,以系统地识别最佳辅助,将其制定为单一逆模拟方案中的双层优化,该方案寻求满足不同辅助设备目标的最佳辅助力矩。
辅助力矩的双层优化被构建为一个内部优化问题,以解决嵌套在外部优化问题中的肌肉冗余问题,外部优化问题迭代执行内部问题,寻求最能满足辅助目标的辅助力矩。我们使用这个框架来预测三种不同目标下的最佳踝关节跖屈、髋关节伸展、髋关节屈曲和髋关节外展辅助:最小化肌肉激活、最小化代谢率和最小化肌肉力矩。本研究使用了12名参与者以偏好速度行走的实验数据。
我们发现,对于给定的辅助目标,最佳力矩轨迹是唯一的;即,辅助目标很重要。辅助轨迹的差异在肌肉层面得到解释,并表现为主动和被动力对净肌肉力矩和肌肉机械功的贡献。有趣的是,预测最小代谢率的辅助力矩的辅助期和峰值时间与实验研究报告的相似。
我们的研究结果表明,在最佳辅助条件下研究人机交互需要明确制定辅助目标。