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接受丁丙诺啡治疗阿片类物质使用障碍的男性和女性失眠症状的社会心理相关因素

Psychosocial Correlates of Insomnia Symptoms Among Women and Men Receiving Buprenorphine Treatment for Opioid Use Disorder.

作者信息

Chithranjan Sajanee, Eglovitch Michelle, Marcus Madison M, Svikis Dace, Alattar Maha, Martin Caitlin E

机构信息

Department of Obstetrics and Gynecology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Department of Psychology, College of Humanities and Sciences, Virginia Commonwealth University, Richmond, VA 23284, USA.

出版信息

NeuroSci. 2025 May 30;6(2):48. doi: 10.3390/neurosci6020048.

Abstract

Insomnia is common in individuals with opioid use disorder (OUD). Biopsychosocial factors are important in sleep health, yet this intersection has yet to be fully elucidated in people on buprenorphine for OUD. The objective is to report on patient-reported biopsychosocial factors among people with and without insomnia, specifically among women and men in outpatient OUD treatment. The parent study enrolled adults stabilized on buprenorphine from February 2022-September 2023. Scores of ≥11 on the Insomnia Severity Index (ISI) indicated clinically significant insomnia. Differences were detected by the presence of insomnia, stratified by men and women, using chi-squared and Fisher's exact tests. Of the overall participants (N = 130), most ( = 77; 59.2%) met the criteria for clinically significant insomnia. Women with insomnia were more likely to report social stressors including discrimination for substance use ( = 0.040), food insecurity ( = 0.032), and transportation difficulties accessing healthcare ( = 0.043) than women without insomnia. Men with insomnia were more likely to report financial difficulties accessing healthcare ( = 0.023) than men without insomnia. These findings provide a unique perspective to consider in the development and implementation of sleep interventions for women and men receiving medication treatment for OUD.

摘要

失眠在患有阿片类物质使用障碍(OUD)的个体中很常见。生物心理社会因素对睡眠健康很重要,但在接受丁丙诺啡治疗OUD的人群中,这一交叉领域尚未得到充分阐明。目的是报告有或没有失眠的患者报告的生物心理社会因素,特别是在门诊OUD治疗中的女性和男性。母研究纳入了2022年2月至2023年9月使用丁丙诺啡病情稳定的成年人。失眠严重程度指数(ISI)得分≥11表明存在临床上显著的失眠。通过失眠的存在进行差异检测,按男性和女性分层,使用卡方检验和费舍尔精确检验。在总体参与者(NN = 130人)中,大多数(n = 77;59.2%)符合临床上显著失眠的标准。与没有失眠的女性相比,有失眠的女性更有可能报告社会压力源,包括因物质使用而受到歧视(P = 0.040)、粮食不安全(P = 0.03)和就医交通困难(P = 0.043)。与没有失眠的男性相比,有失眠的男性更有可能报告就医经济困难(P = 0.023)。这些发现为在为接受OUD药物治疗的女性和男性制定和实施睡眠干预措施时提供了一个独特的视角以供考虑。

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