益生菌和益生元治疗老年功能性便秘
Probiotics and prebiotics in the treatment of functional constipation in the elderly individuals.
作者信息
Xu Li, Guo Jian-Tang, Zhao Jing, Liu Ming-He, Mo Chen
机构信息
Department of Gerontology, The Third Medical Center of PLA General Hospital, Beijing 100039, China.
出版信息
World J Gastrointest Pharmacol Ther. 2025 Jun 5;16(2):105242. doi: 10.4292/wjgpt.v16.i2.105242.
Functional constipation (FC) in elderly individuals is a significant health issue that adversely affects their quality of life, with recent studies indicating a close relationship between this condition and gut microbiota dysbiosis. This review aims to explore the role of the gut microbiota in FC in elderly individuals, analyze the mechanisms of the gut-brain axis, and evaluate the potential use of microecological agents, including probiotics and prebiotics, in modulating the gut microbiota and alleviating constipation symptoms. By integrating the latest research findings, this study seeks to provide new perspectives and intervention strategies for the management of FC in elderly individuals.
老年人功能性便秘（FC）是一个严重的健康问题，会对他们的生活质量产生不利影响，最近的研究表明这种情况与肠道微生物群失调密切相关。本综述旨在探讨肠道微生物群在老年人FC中的作用，分析肠-脑轴的机制，并评估微生态制剂（包括益生菌和益生元）在调节肠道微生物群和缓解便秘症状方面的潜在用途。通过整合最新的研究结果，本研究旨在为老年人FC的管理提供新的视角和干预策略。
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