南亚引起皮肤和软组织感染的细菌病原体及抗生素敏感性：一项范围综述方案

Bacterial pathogens causing skin and soft tissue infections and antibiotic susceptibility in South Asia: a scoping review protocol.

作者信息

Rajendran Rajalakshmi, Chitrapady Shravya, K Haritha, M U Tejashree, Balakrishnan Jayaraj Mymbilly, Thunga Girish

机构信息

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Department of Emergency Medicine, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

出版信息

Syst Rev. 2025 Jul 4;14(1):136. doi: 10.1186/s13643-025-02885-1.

DOI:10.1186/s13643-025-02885-1

PMID:40616178

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12231741/

Abstract

BACKGROUND

Skin and soft tissue infections (SSTIs) have become a global public health threat especially in the Indian context. Secondary complications from untreated skin lesions make the patient life miserable and result in serious adverse effects. The main purpose of this scoping review is to identify the common bacterial pathogens causing SSTIs in South Asia.

METHODS

This scoping review adheres to the Joanna Briggs Institute (JBI) guidelines. The search strategy and screening follow the Peer Review of Electronic Search Strategies (PRESS) checklist, and the review will be reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. The initial search set will follow the keyword such as "bacteria", "microbial susceptibility", and "South Asia". Based on the predetermined inclusion and exclusion criteria, literature search will be carried out at the Cochrane Library, PubMed/MEDLINE, SCOPUS, Embase, CINAHL and Web of Science databases, relevant regional databases, and other grey literature will also be searched to cover maximum information. The data extraction and synthesis will be carried out by the researchers independently and the results will be summarised narratively.

DISCUSSION

The present scoping review seeks to address this gap by synthesizing evidence on the common bacterial pathogens causing SSTIs in children and adults across South Asia and their antibiotic susceptibility profiles. By contextualizing these findings, the review aims to inform region-specific empirical guidelines, ultimately enhancing clinical decision-making and improving patient outcomes in managing SSTIs in South Asia. In summary, the insights of this review are not only critical for improving clinical outcomes but also hold considerable public health significance by informing antimicrobial stewardship strategies and guiding policy efforts to address the growing challenge of antimicrobial resistance in the region.

SCOPING REVIEW REGISTRATION

This research has been registered in the Open Science Framework (OSF) ( https://osf.io/xve49 ).

摘要

背景

皮肤及软组织感染（SSTIs）已成为全球公共卫生威胁，在印度尤其如此。未经治疗的皮肤损伤引发的继发性并发症会让患者生活痛苦，并导致严重的不良后果。本综述的主要目的是确定南亚地区引起皮肤及软组织感染的常见细菌病原体。

方法

本综述遵循乔安娜·布里格斯研究所（JBI）的指南。检索策略和筛选遵循电子检索策略同行评审（PRESS）清单，综述将根据系统评价和Meta分析扩展的范围综述优先报告项目（PRISMA-ScR）指南进行报告。初始检索集将遵循“细菌”“微生物敏感性”和“南亚”等关键词。根据预先确定的纳入和排除标准，将在Cochrane图书馆、PubMed/MEDLINE、SCOPUS、Embase、CINAHL和Web of Science数据库中进行文献检索，还将检索相关区域数据库及其他灰色文献，以获取最多信息。数据提取和综合将由研究人员独立进行，结果将以叙述方式总结。

讨论

本综述旨在通过综合关于南亚儿童和成人中引起皮肤及软组织感染的常见细菌病原体及其抗生素敏感性概况的证据来填补这一空白。通过将这些发现置于具体背景中，本综述旨在为特定区域的经验性指南提供信息，最终加强临床决策并改善南亚地区皮肤及软组织感染的患者治疗效果。总之，本综述的见解不仅对改善临床结果至关重要，而且通过为抗菌药物管理策略提供信息以及指导应对该地区日益严峻的抗菌药物耐药性挑战的政策努力，具有相当大的公共卫生意义。