Suppr超能文献

1996 - 2021年47个国家和地区老年人特定方法的自杀死亡率及到2050年的预测:一项全球时间序列和建模研究

Method-specific suicide mortality rates among older adults in 47 countries and territories, 1996-2021, with projections to 2050: a global time series and modelling study.

作者信息

Cho Hanseul, Kim Soeun, Son Yejun, Jang Wonwoo, Kim Hyeon Jin, Lee Hayeon, Lee Sooji, Oh Jiyeon, Kang Jiseung, Tsai Alexander C, Shinn Ann K, Fond Guillaume, Boyer Laurent, Solmi Marco, Woo Selin, Yon Dong Keon, Fusar-Poli Paolo

机构信息

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

出版信息

Lancet Healthy Longev. 2025 Jul 11:100719. doi: 10.1016/j.lanhl.2025.100719.

Abstract

BACKGROUND

Suicide rates are highest among older adults, yet comprehensive global studies are limited. This study aimed to estimate suicide mortality rates among older adults aged 65 years and older across 47 countries and territories from 1996 to 2021, including analyses by suicide method, project future rates to 2050, and identify associated factors.

METHODS

The study adhered to the Guidelines for Accurate and Transparent Health Estimates Reporting. We extracted suicide mortality data of older adults (≥65 years) across 47 countries and territories from the WHO Mortality Database for the period 1996-2021. We first estimated suicide mortality rates using a locally estimated scatterplot smoothing curve from 1996 to 2021, conducting subanalyses by sex, age subgroup, and suicide method. We then estimated future projections of suicide mortality rates to 2050 via Bayesian age-period-cohort (BAPC) modelling. We also performed a decomposition analysis using the Das Gupta method to identify factors contributing to changes in suicide death numbers between 1996 and 2021. Finally, we examined associations between suicide mortality rates in 2021 or the most recent available year and country-level indicators (poverty rate, disability-adjusted life-year [DALY] rates for alcohol use disorders and mental disorders, civilian firearm ownership, and pesticide use per cropland).

FINDINGS

A total of 687 443 older adults who died by suicide (75·2% men, 24·8% women) were included in the analysis. The suicide mortality rate among adults aged 65 years and older was 15·99 deaths per 100 000 (95% CI 14·19-17·80) in 2021, significantly higher than the all-age suicide mortality rate of 10·87 deaths per 100 000 (9·86-11·87) in 2021 (p<0·0001). Firearms were more frequently used by older adults who died by suicide, compared with the total population (14·91% vs 9·88%, respectively; p<0·0001). The firearm-related suicide mortality rate among older adults was 2·44 per 100 000 (95% CI 2·00-2·89) in 2021, approximately twice that of individuals of all ages (1·09 per 100 000; 0·88-1·31; p<0·0001). There was an overall decline in suicide mortality rates among older adults from 1996 to 2021 (average annual percentage change [AAPC] -1·51 per 100 000; 95% CI -1·52 to -1·50), which was more pronounced among women (AAPC -2·24 per 100 000; -2·28 to -2·21) than in men (AAPC -1·45 per 100 000; -1·48 to -1·42; p<0·0001). Older age subgroups had smaller AAPCs (p<0·0001 for comparisons across all age subgroups). Notably, among adults aged 80 years and older, the suicide mortality rate by firearm showed no statistically significant change between 1996 and 2021. BAPC model projections suggest a slowing in the decline of suicide mortality rates among older adults to 2050. Decomposition analysis indicated that compared with 1996, the total number of suicides in 2021 increased by 7781 deaths primarily due to population growth. Suicide mortality rates among older adults generally increased with higher poverty rates, DALY rates for mental disorders and alcohol use disorders, as well as Human Development Index. Additionally, increasing civilian firearm ownership rates and pesticide use per cropland area were associated with higher suicide mortality rates among older adults who died by firearm and other poisoning, respectively.

INTERPRETATION

Although suicide mortality rates among older adults have declined, the slowing pace of the decline and the rapid ageing of the global population make it an increasing public health concern. Associations between the availability of means such as firearms and pesticides and method-specific suicide rates support existing evidence that restricting access to highly lethal methods can reduce suicide mortality. Variation in suicide methods by sex, age, and country, such as the higher use of firearms among older adults and more frequent use of drug or other poisoning among older women, can inform tailored risk assessments and prevention strategies.

FUNDING

Wellcome Trust and National Research Foundation of Korea.

摘要

背景

老年人的自杀率最高,但全面的全球研究有限。本研究旨在估计1996年至2021年期间47个国家和地区65岁及以上老年人的自杀死亡率,包括按自杀方法进行分析,预测到2050年的未来自杀率,并确定相关因素。

方法

本研究遵循准确和透明的健康估计报告指南。我们从世界卫生组织死亡率数据库中提取了1996 - 2021年期间47个国家和地区老年人(≥65岁)的自杀死亡数据。我们首先使用局部加权散点平滑曲线估计1996年至2021年的自杀死亡率,并按性别、年龄亚组和自杀方法进行亚组分析。然后,我们通过贝叶斯年龄 - 时期 - 队列(BAPC)模型估计到2050年自杀死亡率的未来预测。我们还使用达斯古普塔方法进行分解分析,以确定1996年至2021年期间导致自杀死亡人数变化的因素。最后,我们研究了2021年或最近可用年份的自杀死亡率与国家层面指标(贫困率、酒精使用障碍和精神障碍的伤残调整生命年[DALY]率、民用枪支拥有率以及每农田面积的农药使用量)之间的关联。

结果

共有687443名自杀死亡的老年人(男性占75.2%,女性占24.8%)纳入分析。2021年65岁及以上成年人的自杀死亡率为每10万人15.99例死亡(95%置信区间14.19 - 17.80),显著高于2021年全年龄段每10万人10.87例死亡的自杀死亡率(9.86 - 11.87;p<0.0001)。与总人口相比,自杀死亡的老年人更频繁地使用枪支(分别为14.91%和9.88%;p<0.0001)。2021年老年人中与枪支相关的自杀死亡率为每10万人2.44例(95%置信区间2.00 - 2.89),约为所有年龄段个体(每10万人1.09例;0.88 - 1.31;p<0.0001)的两倍。1996年至2021年期间老年人的自杀死亡率总体呈下降趋势(平均年百分比变化[AAPC]为每10万人 - 1.51;95%置信区间 - 1.52至 - 1.50),女性下降更为明显(AAPC为每10万人 - 2.24; - 2.28至 - 2.21),高于男性(AAPC为每10万人 - 1.45; - 1.48至 - 1.42;p<0.0001)。年龄较大的亚组AAPC较小(所有年龄亚组比较p<0.0001)。值得注意的是,在80岁及以上的成年人中,则1996年至2021年期间枪支导致的自杀死亡率无统计学显著变化。BAPC模型预测表明,到2050年老年人自杀死亡率下降速度将放缓。分解分析表明,与1996年相比,2021年自杀总数增加了7781例死亡,主要是由于人口增长。老年人的自杀死亡率通常随着贫困率、精神障碍和酒精使用障碍的DALY率以及人类发展指数的升高而增加。此外,民用枪支拥有率的增加和每农田面积农药使用量的增加分别与枪支自杀和其他中毒自杀的老年人较高的自杀死亡率相关。

解读

尽管老年人的自杀死亡率有所下降,但下降速度放缓以及全球人口的快速老龄化使其成为日益严重的公共卫生问题。枪支和农药等手段的可得性与特定方法的自杀率之间的关联支持了现有证据:限制获得高致死性方法可以降低自杀死亡率。自杀方法在性别、年龄和国家之间的差异,例如老年人中枪支使用较多,老年女性中药物或其他中毒使用更频繁,可为量身定制的风险评估和预防策略提供参考。

资金来源

惠康信托基金会和韩国国家研究基金会。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验