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一名54岁女性肾脏尤因肉瘤的独特手术病例报告:诊断与治疗挑战

A unique surgical case report of Ewing sarcoma of the kidney in a 54-year-old female: Diagnostic and therapeutic challenges.

作者信息

Mahmoud Mustafa, Ali Aziz Mouslem Haj, Jaara Mostafa Mhd Ali, Ahmed Adnan

机构信息

Urologist - Kidney Transplant Specialist-Damascus hospital, Damascus, Syria.

Urologist - Damascus Hospital, Damascus, Syria.

出版信息

Int J Surg Case Rep. 2025 Aug;133:111615. doi: 10.1016/j.ijscr.2025.111615. Epub 2025 Jul 7.

Abstract

INTRODUCTION

Renal involvement of Ewing sarcoma in adults is extremely rare and tends to be significantly more aggressive in the kidney compared to other anatomical sites. Most cases are diagnosed at an advanced metastatic stage, as in our case, because these tumors are often asymptomatic during the early stages.

CASE PRESENTATION

In our case, the patient presented with sudden, severe right flank pain without any associated urinary symptoms. Imaging revealed a mass in the right kidney, along with metastases to multiple body sites. Surgical intervention was carried out, including radical resection of the tumor and kidney, followed by chemotherapy and radiotherapy.

CLINICAL DISCUSSION

Although rare, Ewing sarcoma should be included in the differential diagnosis of renal tumors in adults due to its aggressive nature and rapid metastatic potential, necessitating prompt and comprehensive management.

CONCLUSION

This case illustrates the rarity and aggressive nature of primary renal Ewing sarcoma in adults, the feasibility of surgery even in metastatic settings when indicated, and the potential for response to standard chemotherapy. It underscores the importance of an individualized, multidisciplinary approach in managing such rare presentations.

摘要

引言

尤因肉瘤在成人中的肾脏受累极为罕见,与其他解剖部位相比,在肾脏中往往更具侵袭性。大多数病例在晚期转移阶段才被诊断出来,就像我们的病例一样,因为这些肿瘤在早期通常没有症状。

病例介绍

在我们的病例中,患者突然出现严重的右侧腰痛,无任何相关泌尿系统症状。影像学检查显示右肾有肿块,并伴有多处身体部位转移。进行了手术干预,包括肿瘤和肾脏的根治性切除,随后进行化疗和放疗。

临床讨论

尽管罕见,但由于尤因肉瘤具有侵袭性和快速转移的潜力,在成人肾肿瘤的鉴别诊断中应考虑到它,这需要及时和全面的管理。

结论

本病例说明了成人原发性肾尤因肉瘤的罕见性和侵袭性,即使在有转移的情况下,手术在有指征时的可行性,以及对标准化疗的反应潜力。它强调了个体化、多学科方法在处理此类罕见病例中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1742/12281440/5b5c361ac73a/gr1.jpg

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