超越血脂水平：揭示家族性高胆固醇血症中的高血压因素。希腊家族性高胆固醇血症登记研究。
Beyond lipid levels: unraveling the hypertensive factor in familial hypercholesterolemia. The HELLAS-FH registry.
作者信息
Antza Christina, Rizos Christos V, Kotsis Vasileios, Liamis George, Skoumas Ioannis, Rallidis Loukianos, Garoufi Anastasia, Sfikas George, Kolovou Genovefa, Penopoulos Athanasios, Skalidis Emmanouil, Stamatelopoulos Kimon, Doumas Michalis, Lambadiari Vaia, Anagnostis Panagiotis, Mavrokefalou Evgenia, Boufidou Amalia, Giannakopoulou Vasiliki, Anastasiou Georgia, Petkou Ermioni, Vlachopoulos Charalambos, Dima Ioanna, Fakas Georgios, Papathanasiou Konstantinos A, Attilakos Achilleas, Koumaras Charalambos, Kolovou Vana, Agapakis Dimitrios, Zacharis Evangelos, Moustou Chrysoula, Katsiki Niki, Kountouri Aikaterini, Mpellou Eleni, Prodromiadou Elisavet, Liberopoulos Evangelos
机构信息
3rd Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
出版信息
J Hum Hypertens. 2025 Sep;39(9):619-625. doi: 10.1038/s41371-025-01052-2. Epub 2025 Jul 21.
Arterial hypertension (AH) and familial hypercholesterolemia (FH) are major risk factors for atherosclerotic cardiovascular disease (ASCVD). The extent to which the coexistence of AH and FH amplifies the ASCVD risk is not well known. We aimed to explore the effect of AH on the prevalence of ASCVD in patients with FH. This was a cross-sectional analysis from the HELLAS-FH registry. A total of 2367 adults with heterozygous FH were studied. Out of these, 602 (25.4%) patients had AH. Patients with AH were more likely to have additional ASCVD risk factors (diabetes, smoking, obesity, elevated triglycerides and reduced high-density lipoprotein cholesterol levels) compared with patients without AH. Patients with AH had significantly higher prevalence of established coronary artery disease (CAD) (44 vs 14%, p < 0.001), premature CAD (39 vs 13%, p < 0.001), stroke (6 vs 2%, p < 0.001), and peripheral artery disease (6 vs 1%, p < 0.001) compared with those without after adjustment for major ASCVD risk factors. Systolic blood pressure (SBP) was significantly associated with increased odds of established CAD per 1 mmHg [odds ratio (OR) 1.075; 95% CI 1.001-1.153; p = 0.048], stroke (OR 1.023; 95% CI 1.004-1.042; p = 0.019) and PAD (OR 1.022; 95% CI 1.002-1.041; p = 0.028), while diastolic blood pressure showed no significant association with these outcomes. In conclusion, AH is associated with higher ASCVD risk factor burden and increased prevalence of ASCVD in patients with FH.
动脉高血压（AH）和家族性高胆固醇血症（FH）是动脉粥样硬化性心血管疾病（ASCVD）的主要危险因素。AH和FH并存会在多大程度上增加ASCVD风险尚不清楚。我们旨在探讨AH对FH患者ASCVD患病率的影响。这是一项来自HELLAS - FH注册研究的横断面分析。共研究了2367名杂合子FH成年患者。其中，602名（25.4%）患者患有AH。与未患AH的患者相比，患AH的患者更有可能有其他ASCVD危险因素（糖尿病、吸烟、肥胖、甘油三酯升高和高密度脂蛋白胆固醇水平降低）。在对主要ASCVD危险因素进行调整后，患AH的患者确诊冠心病（CAD）的患病率显著更高（44%对14%，p < 0.001）、早发CAD（39%对13%，p < 0.001）、中风（6%对2%，p < 0.001）和外周动脉疾病（6%对1%，p < 0.001）。收缩压（SBP）每升高1 mmHg与确诊CAD的几率增加显著相关[比值比（OR）1.075；95%置信区间1.001 - 1.153；p = 0.048]、中风（OR 1.023；95%置信区间1.004 - 1.042；p = 0.019）和外周动脉疾病（OR 1.022；95%置信区间1.002 - 1.041；p = 0.028），而舒张压与这些结果无显著关联。总之，AH与FH患者更高的ASCVD危险因素负担及ASCVD患病率增加相关。
Zotero 插件