肽合成中存在争议的命名法：呼吁明确化。

Controversial Nomenclature in Peptide Synthesis: A Call for Clarity.

作者信息

Sharma Anamika, Kumar Ashish, de la Torre Beatriz G, Albericio Fernando

机构信息

Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

出版信息

J Pept Sci. 2025 Sep;31(9):e70044. doi: 10.1002/psc.70044.

DOI:10.1002/psc.70044

PMID:40716756

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301071/

Abstract

Various approaches to make peptides have been adopted globally owing to their high demand. The three main approaches commonly used for this purpose are solution synthesis, also called classical solution-phase peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase peptide synthesis (LPPS). Each method offers unique advantages: CSPS for scalability, SPPS for automation and efficiency, and LPPS for combining solution-phase simplicity with iterative synthesis using soluble tags.

摘要

由于对肽的需求量很大，全球已采用了各种制备肽的方法。为此目的通常使用的三种主要方法是溶液合成，也称为经典溶液相肽合成（CSPS）、固相肽合成（SPPS）和液相肽合成（LPPS）。每种方法都有其独特的优势：CSPS具有可扩展性，SPPS具有自动化和高效性，LPPS则将溶液相的简单性与使用可溶性标签的迭代合成相结合。