2×4固定正畸治疗在混合牙列期的有效性及临床适应症：一项系统评价

Effectiveness and Clinical Indications of 2 × 4 Fixed Orthodontic Therapy in Regard to Mixed Dentition: A Systematic Review.

作者信息

Dipalma Gianna, Marinelli Grazia, Casamassima Lucia, Nardelli Paola, Ciccarese Danilo, Sena Paolo De, Inchingolo Francesco, Crincoli Vito, Palermo Andrea, Bordea Ioana Roxana, Carbonara Andrea, Inchingolo Angelo Michele, Inchingolo Alessio Danilo

机构信息

Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.

Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.

出版信息

Children (Basel). 2025 Jul 7;12(7):897. doi: 10.3390/children12070897.

DOI:10.3390/children12070897

PMID:40723090

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12293636/

Abstract

BACKGROUND/OBJECTIVES: This systematic review examines the effectiveness and clinical indications of the 2 × 4 fixed orthodontic appliance for interceptive treatment in children with mixed dentition, aiming to simplify future orthodontic needs.

METHODS

Following the PRISMA guidelines, a search was conducted across PubMed, Web of Science, and Scopus (May 2000-May 2025). The inclusion criteria focused on open-access, in vivo/human studies, case-control studies, cohort studies, and RCTs in English. Risk of bias was assessed using Rob 2.0.

RESULTS

Out of 362 initial records, 7 studies were included. Most of the included studies showed a low risk of bias, with some moderate risk in terms of confounding variables and participant selection, but no high risk was identified.

CONCLUSIONS

The 2 × 4 fixed orthodontic appliance is an effective interceptive therapy for mixed dentition. Clinicians can optimize outcomes by understanding its biomechanics and clinical applications. Further research is needed to understand long-term impacts and improve efficiency.

摘要

背景/目的：本系统评价旨在探讨2×4固定正畸矫治器对混合牙列期儿童进行阻断性治疗的有效性和临床适应证，以期简化未来的正畸需求。