Recent Advances in Membrane-Coated Micro/Nanomotors in Biological Applications.

The integration of synthetic micro/nanomotors (MNMs) with natural biomaterials derived from cell membranes has emerged as a highly promising strategy for advancing biological applications. The membrane-coated MNM offers distinct advantages over earlier MNMs dependent on chemical fuels such as hydrogen peroxide, which were prone to poor biocompatibility and harmful byproducts. These include enhanced biocompatibility, immune evasion via natural membrane surfaces, multifunctionality for drug delivery, self-propulsion in complex environments, self-degradation to reduce residual toxicity and inherent imaging capabilities enabling real-time tracking. This review provides a comprehensive overview of the integration of various types of micromotors with natural cell membranes commonly present in the circulatory system. Additionally, it summarizes the methodologies for the preparation, characterization and functional evaluation of biofilm-modified micromotors. The present article also critically examines current developments in biofilm-modified micromotors, addressing their challenges and limitations in enhancing clinical efficacy and facilitating transition to clinical trials in humans.