H5N1 virus invades the mammary glands of dairy cattle through 'mouth-to-teat' transmission.
作者信息
Shi Jianzhong, Kong Huihui, Cui Pengfei, Deng Guohua, Zeng Xianying, Jiang Yongping, He Xijun, Zhang Xianfeng, Chen Lei, Zhuang Yichao, Wang Yan, Ma Jinming, Li Jiaqi, Zhang Yaping, Wang Congcong, He Chen, Yang Jiaxin, Li Jiongjie, Liu Wenyu, Yang Jinyu, Mao Shenggang, Liu Jinxiong, Chen Pucheng, Tian Guobin, Li Chengjun, Guan Yuntao, Bu Zhigao, Chen Hualan
机构信息
State Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
National High Containment Laboratory for Animal Disease Control and Prevention, Harbin 150069, China.
出版信息
Natl Sci Rev. 2025 Jul 1;12(9):nwaf262. doi: 10.1093/nsr/nwaf262. eCollection 2025 Sep.
H5N1 influenza outbreaks have been reported on more than 1070 dairy farms across 17 states in the USA. Damage to the mammary gland and high levels of virus in milk were common features of the infected cattle, but it is unclear how the virus initially invades the mammary glands, and no control strategy is currently available. Here, we found that cattle oral tissues support H5N1 virus binding and replication, and virus replicating in the mouth of cattle transmitted to the mammary glands of dairy cattle during sucking. We also found that an H5 inactivated vaccine or a hemagglutinin-based DNA vaccine induced sterilizing immunity in cows against challenges with different H5N1 viruses. Our study provides insights into H5N1 virus transmission and control in cattle.
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