SIRT6是衰老过程中胰腺β细胞存活和功能的关键调节因子。
SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.
作者信息
Park Jimin, Lokuge Sandali D, Huang Menghao, Wang Shen, Liu Sheng, Liang Jingru, Katturajan Ramkumar, Marakovits Corinn, Yang Zhihong, Wan Jun, Dong X Charlie
机构信息
Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN.
Luddy School of Informatics, Computing, and Engineering, Indiana University, Indianapolis, IN.
出版信息
Diabetes. 2025 Aug 21. doi: 10.2337/db25-0116.
Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.
胰腺β细胞功能随年龄增长而衰退，但其潜在机制尚不清楚。在本研究中，我们试图探讨如何逆转β细胞衰老。我们的数据表明，过表达沉默调节蛋白6（SIRT6）可减少与年龄相关的DNA损伤、细胞死亡以及β细胞功能衰退。我们的研究结果提示，提高Sirt6基因的表达和功能可能会减缓老年患者β细胞的衰退。
Zotero 插件