Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity.

The rapid advancement of vaccines and immunotherapies has significantly improved public health. However, a significant translational gap remains between basic research and clinical application, largely attributed to the disconnect between studies and models. To bridge this gap, models of immune organs, including bone marrow, thymus, spleen, lymph nodes, and tonsils, have emerged as a promising solution. By integrating cutting-edge technologies such as culture, microfluidic chips, engineered tissues, and organoid models, researchers have successfully established a new-generation immune simulation platform. This review systematically summarizes recent progress in immune organ-based models, outlines the current technological landscape and highlights the unique advantages of immune organoids within this field. Notably, we classify immune organoids into strictly and broadly defined categories based on their origin and construction methodology, while emphasizing the importance of multi-model integration. This platform provides a novel framework for advancing translational immunology research, particularly in the fields of adaptive immunity and vaccine development.