非编码RNA（ncRNAs）在白血病干细胞（LSCs）功能中的作用：综述
The roles of non-coding RNAs (ncRNAs) in the function of leukemic stem cells (LSCs): a comprehensive review.
作者信息
Sharifi Mehran, Nekoeian Shahram, Eshraghi Reza, Behzadi Ehsan, Rajabi Ali
机构信息
Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, Kashan University of Reiter Sciences, Kashan, Iran.
出版信息
Discov Oncol. 2025 Aug 25;16(1):1617. doi: 10.1007/s12672-025-02836-1.
All forms of leukemia, including AML, ALL, CML, and CLL, are estimated to make up 2.5% of new cancer diagnoses and 3.1% of all cancer fatalities worldwide. Leukemia is mainly propelled by LSCs that possess remarkable self-renewal and differentiation abilities, comparable to those of regular HSCs. The presence of LSCs is crucial for the progress and amplification of leukemia, as they enable evasion of the immune system and resilience to therapy. ncRNAs have emerged as a potential means of regulating various forms of cancer, owing to their role in diverse cellular processes. Long non-coding RNAs, microRNAs, and Circular RNAs are among the most studied ncRNAs and exert control over the expression of numerous proteins related to the advancement of malignancies. Given the importance of LSCs in leukemia and the potential of ncRNAs, we aimed to explore the ncRNAs abnormally expressed in leukemia and investigate them as therapeutic targets. In addition, in our review, we thoroughly examined the ncRNAs responsible for conferring chemo-resistance to LSCs.
据估计，包括急性髓系白血病（AML）、急性淋巴细胞白血病（ALL）、慢性髓系白血病（CML）和慢性淋巴细胞白血病（CLL）在内的所有白血病形式，占全球新癌症诊断病例的2.5%，占所有癌症死亡病例的3.1%。白血病主要由白血病干细胞（LSCs）驱动，这些细胞具有与正常造血干细胞相当的显著自我更新和分化能力。白血病干细胞的存在对于白血病的进展和扩增至关重要，因为它们能够逃避免疫系统并耐受治疗。由于非编码RNA（ncRNAs）在多种细胞过程中发挥作用，它们已成为调节各种癌症的一种潜在手段。长链非编码RNA、微小RNA和环状RNA是研究最多的ncRNAs，它们控制着许多与恶性肿瘤进展相关蛋白质的表达。鉴于白血病干细胞在白血病中的重要性以及ncRNAs的潜力，我们旨在探索白血病中异常表达的ncRNAs，并将它们作为治疗靶点进行研究。此外，在我们的综述中，我们全面研究了赋予白血病干细胞化疗抗性的ncRNAs。
Zotero 插件