β-环糊精功能化银纳米颗粒的合成、性质及其对羽扇豆碱及其乙酰衍生物的负载

Synthesis and Properties of Silver Nanoparticles Functionalized with β-Cyclodextrin and Their Loading with Lupinine and Its Acetyl Derivatives.

作者信息

Fazylov Serik D, Nurmaganbetov Zhangeldy S, Nurkenov Oralgazy A, Sarsenbekova Akmaral Z, Seilkhanov Olzhas T, Seidakhmetova Roza B, Mendibayeva Anel Z, Bakirova Ryszhan Y, Muldakhmetov Zainulla M

机构信息

Laboratory of Synthesis of Biologically Active Substances, Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan.

Department of Physical and Analytical Chemistry, Karaganda University of the Name of E.A. Buketov, Karaganda 100074, Kazakhstan.

出版信息

Molecules. 2025 Aug 12;30(16):3354. doi: 10.3390/molecules30163354.

DOI:10.3390/molecules30163354

PMID:40871507

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12388491/

Abstract

This study presents the results of a study of the synthesis and properties of 2-hydroxy-β-cyclodextrin functionalized by silver nanoparticles and its loading with a bioactive component. As a reducing agent and stabilizer, 2-Hydroxy-β-cyclodextrin (2gβCD) was used in the production of silver nanoparticles. The use of 2gβCD-AgNPs in loading molecules of the plant alkaloid lupinine (Lup) and its acetyl derivative (Lac) with bactericidal properties were studied. The formation of Lup-2gβCD-AgNPs and Lac-2gβCD-AgNPs was confirmed by UV spectroscopy and X-ray diffraction spectroscopy (XRD). Transmission electron microscopy (TEM) showed that the synthesized AgNPs had a spherical shape. H-, C-NMR nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy (FT-IR) confirmed the reduction and encapsulation of AgNPs by 2gβCD. Thermographic data show that the obtained Lup and its derivative inclusion complexes reduced energy barriers. This makes them promising components for thermosensitive functional materials. Encapsulated complexes of Lup and its acetate inclusion with silver nanoparticles demonstrated significantly ( < 0.05) higher antibacterial, cytotoxic, and moderately pronounced analgesic activity.

摘要

本研究展示了一项关于银纳米颗粒功能化的2-羟基-β-环糊精的合成及其性质以及其负载生物活性成分的研究结果。作为还原剂和稳定剂，2-羟基-β-环糊精（2gβCD）被用于银纳米颗粒的制备。研究了2gβCD-AgNPs对具有杀菌特性的植物生物碱羽扇豆碱（Lup）及其乙酰衍生物（Lac）分子的负载情况。通过紫外光谱和X射线衍射光谱（XRD）证实了Lup-2gβCD-AgNPs和Lac-2gβCD-AgNPs的形成。透射电子显微镜（TEM）显示合成的AgNPs呈球形。H-、C-核磁共振光谱和傅里叶变换红外光谱（FT-IR）证实了2gβCD对AgNPs的还原和包封。热成像数据表明，所得到的羽扇豆碱及其衍生物包合物降低了能垒。这使得它们成为热敏功能材料的有前景的成分。羽扇豆碱及其乙酸酯与银纳米颗粒的包封复合物表现出显著（<0.05）更高的抗菌、细胞毒性和中度明显的镇痛活性。