A Conversational Agent (PracticePal) to Support the Delivery of a Brief Behavioral Activation Treatment for Depression in Rural India: Development and Pilot-Testing Study.

BACKGROUND

Brief psychosocial interventions, such as the Healthy Activity Program (HAP), which are based on behavioral activation and delivered by nonspecialist providers (NSPs), have emerged as cost-effective solutions for the treatment of depression. HAP treatment outcomes are improved by the engagement of patients in activation-focused homework assignments and their adherence to these assignments during therapy. Currently, patients are expected to complete these homework assignments using a paper workbook.

OBJECTIVE

The aim of this study was to describe the user-centered development process of PracticePal, a chatbot designed to enhance patient engagement and homework adherence, and to evaluate its feasibility and acceptability as a therapy aid in India.

METHODS

We used a user-centered approach to co-develop PracticePal, incorporating conversational flows and video scripts in Hindi. The chatbot was piloted with 30 participants having depression who were receiving the HAP from 15 nonspecialist counselors in primary care in rural Madhya Pradesh, India. The feasibility and acceptability of PracticePal were assessed through engagement data, in-depth interviews with a subset of 6 participants, and focus group discussions with 11 counselors. Treatment completion rates and changes in depressive symptoms were explored as secondary outcomes.

RESULTS

Average patient engagement spanned 29 days (95% CI 24-34) during the 60-day treatment period. The engagement of patients with PracticePal increased as their treatment progressed, particularly after the third HAP session. Of the 30 patients, 20 (67%) accessed more than half of the multimedia content available on the chatbot. On average, there was a greater frequency of self-initiated engagement (1558 out of a total of 1835 times, 84.9%) across all sessions compared with reminder prompts (277 out of 1835 times, 15.1%). All 30 patients completed treatment and experienced a reduction in the mean Patient Health Questionnaire-9 score from 13 (95% CI 12.6-13.6; signifying moderate severity) to 4 (95% CI 2.9-4.7; signifying none/minimal severity). Patients found the chatbot's reminders for activities, mood tracking, and video messages helpful and observed that it could help others in their social network. NSPs also reported improved participation of patients in the homework tasks compared with the paper workbook. A few patients faced challenges with low internet bandwidth, and those with limited literacy suggested increasing the amount of video content for easier accessibility.

CONCLUSIONS

The PracticePal chatbot is a feasible and acceptable therapy aid to complement a psychological treatment, with promising potential to enhance the effectiveness of NSP-delivered psychosocial interventions in low-resource settings. Future steps include conducting a fully powered randomized controlled trial to assess its effectiveness in improving mental health outcomes.