环状RNA中的内部核糖体进入位点

The Internal Ribosome Entry Site in Circular RNAs.

作者信息

Fernandes Queenie, Yoosuf Zeenath Safira K M, Mestiri Sarra, Assami Laila, Makni-Maalej Karama, Uddin Shahab, Merhi Maysaloun, Dermime Said

机构信息

Translational Cancer Research Facility, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

College of Medicine, Qatar University, Doha, Qatar.

出版信息

Adv Exp Med Biol. 2025;1485:131-148. doi: 10.1007/978-981-96-9428-0_9.

DOI:10.1007/978-981-96-9428-0_9

PMID:40886274

Abstract

The internal ribosome entry site (IRES) within circular RNAs (circRNAs) has emerged as a dynamic and multifaceted regulatory element, challenging traditional notions of translation initiation in eukaryotic cells. This chapter reviews the current state of research and knowledge on IRES in circRNAs, exploring its molecular mechanisms, physiological roles, and therapeutic implications. As the field continues to evolve, research efforts are essential for a comprehensive understanding of the interplay between IRES and circRNAs. This work also highlights the future directions in the study of IRES within circRNAs, underscoring its significance in gene expression regulation and opening new avenues for therapeutic innovation.

摘要

环状RNA（circRNA）中的内部核糖体进入位点（IRES）已成为一种动态且多方面的调控元件，挑战了真核细胞中传统的翻译起始观念。本章综述了目前关于circRNA中IRES的研究现状和知识，探讨了其分子机制、生理作用及治疗意义。随着该领域的不断发展，研究工作对于全面理解IRES与circRNA之间的相互作用至关重要。这项工作还突出了circRNA中IRES研究的未来方向，强调了其在基因表达调控中的重要性，并为治疗创新开辟了新途径。