古菌中的环状RNA

Circular RNAs in Archaea.

作者信息

Becker Hubert F, Ferreira-Cerca Sébastien

机构信息

Laboratoire d'Optique et Biosciences (CNRS UMR7645, INSERM U1182), École Polytechnique, Institut polytechnique de Paris, Palaiseau, France.

Faculté des Sciences et Ingénierie, Sorbonne Université, Paris, France.

出版信息

Adv Exp Med Biol. 2025;1485:451-464. doi: 10.1007/978-981-96-9428-0_26.

DOI:10.1007/978-981-96-9428-0_26

PMID:40886291

Abstract

Circular RNA molecules were first described more than 40 years ago. However, it is only recently that the broadness of their phylogenetic distribution has been revealed. Since their discoveries, numerous studies have characterized the molecular mechanisms and function underlying these peculiar molecules, mostly in diverse eukaryotic species. In contrast, studies focusing on the biology of circular RNAs in archaea remain relatively scarce.In this chapter, we provide an overview of the discovery of circular RNAs in archaea and summarize our knowledge of their biology, with an emphasis on circular pre-ribosomal RNAs and Box C/D RNAs.

摘要

环状RNA分子早在40多年前就被首次描述。然而，直到最近它们系统发育分布的广度才被揭示出来。自发现以来，众多研究已经阐明了这些特殊分子背后的分子机制和功能，这些研究大多针对不同的真核生物物种。相比之下，针对古菌中环状RNA生物学的研究仍然相对较少。在本章中，我们概述了古菌中环状RNA的发现，并总结了我们对其生物学的了解，重点是环状前核糖体RNA和C/D盒RNA。