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微量营养素失衡、临床表现及干预措施的范围综述

Scoping review of micronutrient imbalances, clinical manifestations, and interventions.

作者信息

English Kevan, Uwibambe Christine, Daniels Pretty, Dzukey Elfreda

机构信息

Department of Internal Medicine, University of Nebraska Medical Center College of Medicine, Omaha, NE 68198, United States.

Department of Internal Medicine, Jersey Shore University Medical Center, Neptune, NJ 07753, United States.

出版信息

World J Methodol. 2025 Dec 20;15(4):107664. doi: 10.5662/wjm.v15.i4.107664.

Abstract

Micronutrients are fundamental to support and maintain normal physiological function. Deficiencies of these nutrients are a growing public health concern with potentially devastating consequences. An adequate diet of whole foods is the primary source of micronutrients; supplementation is sometimes necessary. Both deficiency and excess of these nutrients have adverse effects. Common deficiencies include iron, folate, iodine, zinc, and vitamin A, which can present clinically as a syndrome. Micronutrient deficiencies (MNDs) are common contributors to intellectual impairments, poor growth, perinatal complications, and increased risk for morbidity and mortality. Excess of a select few of these nutrients can result in conditions such as idiopathic intracranial hypertension and diarrhea. Interventions, including supplementation, fortification, and biofortification, can help combat MNDs. This article reviews some common micronutrient imbalances, their clinical manifestations, and treatment interventions.

摘要

微量营养素是支持和维持正常生理功能的基础。这些营养素的缺乏是一个日益严重的公共卫生问题,可能会带来毁灭性后果。均衡的全食物饮食是微量营养素的主要来源;有时需要进行补充。这些营养素的缺乏和过量都会产生不良影响。常见的缺乏包括铁、叶酸、碘、锌和维生素A,临床上可能表现为一种综合征。微量营养素缺乏(MNDs)是导致智力障碍、生长发育不良、围产期并发症以及发病和死亡风险增加的常见因素。其中少数几种营养素过量会导致诸如特发性颅内高压和腹泻等病症。包括补充、强化和生物强化在内的干预措施有助于对抗微量营养素缺乏。本文综述了一些常见的微量营养素失衡情况、其临床表现以及治疗干预措施。

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