MAGdb：一个用于探索微生物宏基因组组装基因组的全面高质量宏基因组组装基因组（MAGs）库。

MAGdb: a comprehensive high quality MAGs repository for exploring microbial metagenome-assemble genomes.

作者信息

Ye Guo, Hong Hao, Li Ting, Li Jin, Wu Jia-Qi, Jiang Shuai, Meng Zhi-Tong, Yuan He-Tian, Xue Wen, Li Ai-Ling, Zhou Tao, Li Ting-Ting, Li Tao

机构信息

Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang, Hangzhou, 310029, China.

Nanhu Laboratory, State Key Laboratory of Biomedical Analysis (SKLBA), Beijing, 100850, China.

出版信息

Genome Biol. 2025 Sep 10;26(1):276. doi: 10.1186/s13059-025-03711-6.

DOI:10.1186/s13059-025-03711-6

PMID:40931350

Abstract

Metagenomic analyses of microbial communities have unveiled a substantial level of interspecies and intraspecies genetic diversity by reconstructing metagenome-assembled genomes (MAGs). The MAG database (MAGdb) boasts an impressive collection of 74 representative research papers, spanning clinical, environmental, and animal categories and comprising 13,702 paired-end run accessions of metagenomic sequencing and 99,672 high quality MAGs with manually curated metadata. MAGdb provides a user-friendly interface that users can browse, search, and download MAGs and their corresponding metadata information. It represents a valuable resource for researchers in discovering potential novel microbial lineages and understanding their ecological roles. MAGdb is publicly available at https://magdb.nanhulab.ac.cn/ .

摘要

通过重建宏基因组组装基因组（MAG），对微生物群落的宏基因组分析揭示了种间和种内相当程度的遗传多样性。宏基因组组装基因组数据库（MAGdb）拥有74篇具有代表性的研究论文，涵盖临床、环境和动物类别，包括13702个宏基因组测序的双端运行序列登录号以及99672个带有手动整理元数据的高质量宏基因组组装基因组。MAGdb提供了一个用户友好的界面，用户可以浏览、搜索和下载宏基因组组装基因组及其相应的元数据信息。它是研究人员发现潜在新微生物谱系并了解其生态作用的宝贵资源。MAGdb可在https://magdb.nanhulab.ac.cn/ 上公开获取。