基于电子患者报告结局的系统护士主导咨询对子宫内膜癌或卵巢癌女性化疗期间的影响——一项可行性研究

Systematic nurse-led consultations based on electronic patient-reported outcomes for women with endometrial or ovarian cancer during chemotherapy-a feasibility study.

作者信息

Christiansen Mille Guldager, Pappot Helle, Jarden Mary, Tolver Anders, Mikkelsen Hjalte Søberg, Mirza Mansoor Raza, Piil Karin

机构信息

Department of Oncology, Centre for Cancer and Organ Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

出版信息

Support Care Cancer. 2025 Sep 17;33(10):858. doi: 10.1007/s00520-025-09875-y.

DOI:10.1007/s00520-025-09875-y

PMID:40963057

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12443879/

Abstract

PURPOSE

This study aimed to investigate the feasibility of nurse-led consultations based on ePRO for women with endometrial or ovarian cancer receiving chemotherapy.

METHODS

This was a prospective single-cohort feasibility study. The patients responded to weekly ePRO using the Elekta Kaiku platform, which was adapted to Danish. At selected time points during chemotherapy, nurses conducted nurse-led consultations replacing physicians. The primary outcome was the patient completion rate of ePRO reporting in the Elekta Kaiku platform. Secondary outcomes included assessing safety, acceptability, practicability, usability, patient satisfaction with ePRO, and patient symptom burden.

RESULTS

Twenty patients were included, with a mean age of 59 years. A total of 320 ePRO reports were received, equivalent to an ePRO response of 18 times per patient during six cycles of chemotherapy. The results showed a high weekly completion rate (87%), high patient satisfaction with ePRO, and a continuous high symptom burden. Nurse-led consultations achieved a success rate of 55% in adhering to scheduled appointments. The primary contributing factors to this issue were the inadequate internal workflows and the complex symptom burden experienced by the patients.

CONCLUSION

This study indicates that weekly ePRO reporting in conjunction with nurse-led consultations may be feasible in this population. The use of ePRO revealed a high level of symptoms reported by patients throughout the treatment cycles. The results emphasize the importance of clinicians in proactively and systematically intervening at an early stage to prevent symptom escalation. However, the small sample size limits the generalizability of this study.

TRIAL REGISTRATION

This study was registered at the Capital Region of Denmark (P-2021-179) and approved the 10/03/2021. ClinicalTtrials.gov ID: NTCC04945187.

摘要

目的

本研究旨在探讨基于电子患者报告结局（ePRO）的护士主导咨询模式在接受化疗的子宫内膜癌或卵巢癌女性患者中的可行性。

方法

这是一项前瞻性单队列可行性研究。患者使用适配丹麦语的医科达凯库（Elekta Kaiku）平台每周进行一次电子患者报告结局（ePRO）反馈。在化疗的选定时间点，由护士主导咨询，取代医生。主要结局是医科达凯库平台上电子患者报告结局（ePRO）报告的患者完成率。次要结局包括评估安全性、可接受性、实用性、易用性、患者对电子患者报告结局（ePRO）的满意度以及患者症状负担。

结果

纳入20例患者，平均年龄59岁。共收到320份电子患者报告结局（ePRO）报告，相当于每位患者在六个化疗周期中平均反馈18次。结果显示每周完成率较高（87%），患者对电子患者报告结局（ePRO）的满意度较高，且症状负担持续较高。护士主导的咨询在遵守预约方面的成功率为55%。导致该问题的主要因素是内部工作流程不完善以及患者经历的复杂症状负担。