在移植了同基因或异基因胸腺的裸鼠中分化的宿主来源T细胞的活性。
Activity of host-derived T cells which differentiate in nude mice grafted with co-isogenic or allogeneic thymuses.
作者信息
Kindred B, Loor F
出版信息
J Exp Med. 1974 May 1;139(5):1215-27. doi: 10.1084/jem.139.5.1215.
Abstract
If nude mice are grafted with a neonatal thymus, host type precursor cells develop within the graft thymus and after about 6 wk the T-cell population of the thymus, spleen, and lymph nodes is of host type. However, immunological responsiveness produced in nude mice in this manner is incomplete: (a) the ability to react to T-cell mitogens in vitro is greater than in untreated nudes but lower than in normal mice; (b) the response to T-cell dependent antigens is less than normal; and (c) the rejection of skin grafts is slower than in normal animals. Whether host precursor cells which differentiate in an allogeneic thymus are able to reject skin grafts from thymus donor strain appears to depend on the strain combination used.
摘要
如果将新生胸腺移植到裸鼠体内，宿主型前体细胞会在移植的胸腺内发育，大约6周后，胸腺、脾脏和淋巴结中的T细胞群体即为宿主型。然而，以这种方式在裸鼠中产生的免疫反应性是不完全的：（a）体外对T细胞有丝分裂原的反应能力比未处理的裸鼠强，但比正常小鼠弱；（b）对T细胞依赖性抗原的反应低于正常水平；（c）皮肤移植的排斥反应比正常动物慢。在同种异体胸腺中分化的宿主前体细胞是否能够排斥来自胸腺供体品系的皮肤移植，似乎取决于所使用的品系组合。
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