关于O抗原作为从沙门氏菌制备的“核糖体”疫苗中抗原决定簇的证据。
Evidence for O antigens as the antigenic determinants in "ribosomal" vaccines prepared from Salmonella.
作者信息
Eisenstein T K
出版信息
Infect Immun. 1975 Aug;12(2):364-77. doi: 10.1128/iai.12.2.364-377.1975.
Abstract
The nature of the protective substance in ribosomal ribonucleic acid and protein extracts of Salmonella has been investigated. The results of experiments in which vaccines were prepared from isogenic strains and strains with defects in lipopolysaccharide synthesis show that O antigens contaminate both ribonucleic acid and protein ribosomal extracts, and are responsible for at least part of their strain-specific protective activity. In addition, it was observed that a ribosomal ribonucleic acid preparation from S. adelaide contains a heat-stable immunogen which is not an O antigen or that gives cross-protection across species lines. The contribution of ribosomes to the immunity induced by "ribosomal vaccines" is discussed.
摘要
对沙门氏菌核糖体核糖核酸和蛋白质提取物中保护物质的性质进行了研究。用同基因菌株和脂多糖合成有缺陷的菌株制备疫苗的实验结果表明，O抗原污染了核糖核酸和蛋白质核糖体提取物，并至少对其部分菌株特异性保护活性负责。此外，观察到来自阿德莱德沙门氏菌的核糖体核糖核酸制剂含有一种热稳定免疫原，它不是O抗原，或者能提供跨物种的交叉保护。文中讨论了核糖体对“核糖体疫苗”诱导的免疫的贡献。
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