新生期胸腺切除对瑞士白化小鼠抗绵羊红细胞溶血素反应的影响。对总抗体、19S抗体和7S抗体的时间进程研究。
Effects of neonatal thymectomy on the haemolysin response to sheep erythrocytes in Swiss albino mice. A time-course study of total, 19S and 7S antibody.
作者信息
Sinclair N R
出版信息
Immunology. 1967 May;12(5):549-57.
Abstract
Mice thymectomized within 24 hours of birth were immunized by intraperitoneal injection of sheep erythrocytes at 6 weeks of age and again 60 days later. Serum haemolysin activity was measured at various times following antigen injection. The serum haemolysin was fractionated by sucrose gradient centrifugation into two classes. A time-course of the antibody response was constructed for total, 19S and 7S haemolysins. Both reduction in circulating antibody activity and delay in reaching maximal levels were observed.
摘要
出生后24小时内进行胸腺切除的小鼠，在6周龄时通过腹腔注射绵羊红细胞进行免疫，并在60天后再次免疫。在注射抗原后的不同时间测量血清溶血素活性。血清溶血素通过蔗糖梯度离心法分为两类。构建了总溶血素、19S溶血素和7S溶血素抗体反应的时间进程。观察到循环抗体活性降低和达到最大水平的延迟。
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引用本文的文献
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