98名子宫内接触己烯雌酚的女性及其母亲和未接触的兄弟姐妹的妊娠结局。

Pregnancy outcome in 98 women exposed to diethylstilbestrol in utero, their mothers, and unexposed siblings.

作者信息

Mangan C E, Borow L, Burtnett-Rubin M M, Egan V, Giuntoli R L, Mikuta J J

出版信息

Obstet Gynecol. 1982 Mar;59(3):315-9.

Abstract

The reproductive capability and labor complications of 98 women exposed to diethylstilbestrol (DES) in utero were compared with those of 3 separate control groups. The controls consisted of 167 age-matched, normal women, 20 siblings not exposed to DES who had achieved pregnancy, and their mothers. Spontaneous abortion, ectopic pregnancy, incompetent cervix, and premature labor occurred significantly more often in the DES-exposed population than in the normal controls. The controls also achieved a higher percentage of desired pregnancies overall; this was statistically significant (89.6 versus 75.0%, P less than .001). When compared with their mothers, however, the DES-exposed population achieved a greater percentage of desired, viable pregnancies (75.6 versus 67.0%, P less than .001). The unexposed siblings of the DES women achieved a higher percentage of desired, viable pregnancies than did their exposed sisters (86.9 versus 73.6%, P = .274), but less than the normal population (86.9 versus 89.6%).

摘要

对98名子宫内接触己烯雌酚（DES）的女性的生殖能力和分娩并发症与3个不同对照组进行了比较。对照组包括167名年龄匹配的正常女性、20名未接触DES但已怀孕的兄弟姐妹及其母亲。与正常对照组相比，接触DES人群的自然流产、宫外孕、宫颈机能不全和早产发生率明显更高。对照组总体上实现期望妊娠的比例也更高；这具有统计学意义（89.6%对75.0%，P＜0.001）。然而，与她们的母亲相比，接触DES人群实现期望、活产妊娠的比例更高（75.6%对67.0%，P＜0.001）。DES女性未接触的兄弟姐妹实现期望、活产妊娠的比例高于其接触DES的姐妹（86.9%对73.6%，P = 0.274），但低于正常人群（86.9%对89.6%）。