细胞衰老的承诺理论：永生二倍体细胞系的可能性。

Commitment theory of cellular aging: possibility of an immortal diploid cell strain.

作者信息

Hirsch H R

出版信息

Mech Ageing Dev. 1980 Jan;12(1):25-30. doi: 10.1016/0047-6374(80)90025-1.

Abstract

Calculations based on the commitment theory of cellular aging indicate that the mean number of uncommitted cells is much greater than unity in populations consisting of 10(10) or more diploid cells. Consequently the probability that all of the uncommitted cells will be lost by in vitro subcultivation is very small. It may therefore be possible to establish a cell population in the laboratory which is, for all practical purposes, immortal.

摘要

基于细胞衰老的承诺理论进行的计算表明，在由10¹⁰个或更多二倍体细胞组成的群体中，未承诺细胞的平均数量远大于1。因此，所有未承诺细胞在体外传代培养中丢失的概率非常小。所以，在实验室中有可能建立一个在所有实际用途上都可永生的细胞群体。