转运RNA的系统发生似乎证实了遗传密码起源的共同进化理论的预测。
The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code.
作者信息
Di Giulio M
机构信息
International Institute of Genetics and Biophysics, CNR, Napoli, Italy.
出版信息
Orig Life Evol Biosph. 1995 Dec;25(6):549-64. doi: 10.1007/BF01582024.
An extensive analysis of the evolutionary relationships existing between transfer RNAs, performed using parsimony algorithms, is presented. After building up an estimate of the tRNA ancestral sequences, these sequences are then compared using certain methods. The results seem to suggest that the coevolution hypothesis (Wong, J.T., 1975, Proc. Natl. Acad. Sci. USA 72, 1909-1912) that sees the genetic code as a map of the biosynthetic relationships between amino acids is further supported by these results, as compared to the hypotheses that see the physicochemical properties of amino acids as the main adaptative theme that led to the structuring of the genetic code.
本文展示了一项使用简约算法对转运RNA之间存在的进化关系进行的广泛分析。在构建了转运RNA祖先序列的估计值之后，然后使用某些方法对这些序列进行比较。结果似乎表明，与将氨基酸的物理化学性质视为导致遗传密码结构的主要适应性主题的假设相比，将遗传密码视为氨基酸之间生物合成关系图谱的共进化假说（Wong, J.T., 1975, Proc. Natl. Acad. Sci. USA 72, 1909 - 1912）得到了这些结果的进一步支持。
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