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腹主动脉瘤切除术后的肺部并发症及发病率:术后硬膜外镇痛与胃肠外阿片类镇痛的比较

Postoperative pulmonary complications and morbidity after abdominal aneurysmectomy: a comparison of postoperative epidural versus parenteral opioid analgesia.

作者信息

Major C P, Greer M S, Russell W L, Roe S M

机构信息

Department of Surgery, Chattanooga Unit, University of Tennessee College of Medicine, USA.

出版信息

Am Surg. 1996 Jan;62(1):45-51.

PMID:8540645
Abstract

Patients undergoing aortic aneurysm repair have a high prevalence of coexisting cardiac and pulmonary disease, and the postoperative recovery is especially delayed by pulmonary complications. A review of all elective abdominal aneurysm repairs over a 29-month period was undertaken to evaluate the effectiveness of postoperative epidural analgesia in decreasing morbidity and mortality, and specifically pulmonary complications. Patients were placed into two groups; Group 1 (34 patients) used an epidural catheter for postoperative pain control, and Group II (31 patients) used standard parenteral opioid analgesia. The two groups were similar in preoperative combined factors including known risk factors for atherosclerotic cardiovascular disease, preexisting cardiac or pulmonary disease, and preexisting renal insufficiency. A statistically significant decrease (P = < 0.05) was found in both cardiac (P = 0.0002) and pulmonary (P = 0.019) complications in comparison, favoring Group I patients. A significant decrease was also seen in the time to liquid intake (P = 0.044), time out of bed to a chair (P = 0.002), length of stay in the Intensive Care Unit (P = 0.024), and overall hospital charges (P = 0.046) in favor of Group I patients. Although no significant difference (P = > 0.05) was seen in decreasing time to ambulation (P = 0.054), average time required on the ventilator (P = 0.053), or hospital days (P = 0.181), all of these did show a trend in favor of epidural catheter utilization. There were no complications or infections related to the use of the epidural catheter during this study period. In conclusion, the use of an epidural catheter for postoperative pain control has been shown to decrease time of intubation, time in the ICU, number of cardiac and pulmonary complications, which should lead to an overall decrease in hospital charges after elective repair of abdominal aortic aneurysms.

摘要

接受主动脉瘤修复手术的患者并存心脏和肺部疾病的患病率很高,术后恢复尤其会因肺部并发症而延迟。我们对29个月内所有择期腹部动脉瘤修复手术进行了回顾,以评估术后硬膜外镇痛在降低发病率和死亡率,特别是肺部并发症方面的有效性。患者被分为两组;第一组(34例患者)使用硬膜外导管进行术后疼痛控制,第二组(31例患者)使用标准的胃肠外阿片类镇痛。两组在术前综合因素方面相似,包括已知的动脉粥样硬化性心血管疾病危险因素、既往存在的心脏或肺部疾病以及既往存在的肾功能不全。相比之下,第一组患者在心脏(P = 0.0002)和肺部(P = 0.019)并发症方面均有统计学显著降低(P = < 0.05)。在液体摄入时间(P = 0.044)、下床到椅子上的时间(P = 0.002)、重症监护病房住院时间(P = 0.024)和总体住院费用(P = 0.046)方面也有显著降低,均有利于第一组患者。虽然在减少行走时间(P = 0.054)、呼吸机平均使用时间(P = 0.053)或住院天数(P = 0.181)方面未观察到显著差异(P = > 0.05),但所有这些均显示出有利于使用硬膜外导管的趋势。在本研究期间,未发生与硬膜外导管使用相关的并发症或感染。总之,使用硬膜外导管进行术后疼痛控制已被证明可减少插管时间、在重症监护病房的时间、心脏和肺部并发症的数量,这应会导致择期修复腹主动脉瘤后总体住院费用的降低。

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