ERM（埃兹蛋白/根蛋白/膜突蛋白）家族：从细胞骨架到信号转导

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction.

作者信息

Tsukita S, Yonemura S

机构信息

Department of Cell Biology, Faculty of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606, Japan.

出版信息

Curr Opin Cell Biol. 1997 Feb;9(1):70-5. doi: 10.1016/s0955-0674(97)80154-8.

DOI:10.1016/s0955-0674(97)80154-8

PMID:9013673

Abstract

The ERM family consists of three closely related proteins, ezrin, radixin, and moesin, that are thought to work as cross-linkers between plasma membranes and actin-based cytoskeletons. Recent analyses of the structure and functions of ERM proteins have revealed that these molecules are involved not only in cytoskeletal organization but also in signal transduction. Furthermore, identification of the neurofibromatosis type 2 tumour suppressor, which shows striking sequence similarity to ERM proteins, has increased interest in this family.

摘要

ERM家族由三种密切相关的蛋白质组成，即埃兹蛋白、根蛋白和膜突蛋白，它们被认为是质膜和肌动蛋白细胞骨架之间的交联蛋白。最近对ERM蛋白结构和功能的分析表明，这些分子不仅参与细胞骨架的组织，还参与信号转导。此外，与ERM蛋白具有显著序列相似性的2型神经纤维瘤病肿瘤抑制因子的鉴定，增加了人们对这个家族的兴趣。